ファイル情報(添付) | |
タイトル |
Possible Role of Prostaglandins in the Regulation of Insulin Release from Rat Pancreatic Islets
|
著者 |
正木 洋治
谷川 敬一郎
大国 智司
土山 真一
野手 信哉
|
収録物名 |
Shimane journal of medical science
|
巻 | 9 |
号 | 1 |
開始ページ | 21 |
終了ページ | 28 |
収録物識別子 |
ISSN 03865959
EISSN 24332410
|
内容記述 |
抄録・要旨
To clarify whether prostaglandin synthesis is involved in the regulation of insulin release from isolated rat islets, we performed three different experiments. The direct effects of prostaglandin E_1 and prostacyclin on insulin release were investigated. Neither prostaglandin had any effect in the presence of low and high concentrations of glucose. Indomethacin, aspirin^<[○!R]> (acetylsalicylic acid) and flurbiprofen, inhibitors of cyclooxygenase, did not have a significant effect on insulin release evoked by glucose. Exogenous phospholipase A_2 purified from bee venom and melittin stimulated insulin release. A potent and selective inhibitor of phospholipase A_2,mepacrine, inhibited glucose-induced insulin release. The present work indicates that 1) cyclooxygenase does not participate early release of insulin from islet 2) activation of phospholipase A_2 might be involved in insulin stimulus-secretion coupling.
|
主題 |
Langerhans' islet
prostaglandins
insulin release
|
言語 |
英語
|
資源タイプ | 紀要論文 |
出版者 |
Shimane Medical University
|
発行日 | 1985-11-01 |
出版タイプ | Version of Record(出版社版。早期公開を含む) |
アクセス権 | オープンアクセス |
関連情報 |
[NCID] AA00841586
|