Possible Role of Prostaglandins in the Regulation of Insulin Release from Rat Pancreatic Islets

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タイトル
Possible Role of Prostaglandins in the Regulation of Insulin Release from Rat Pancreatic Islets
著者
正木 洋治
谷川 敬一郎
大国 智司
土山 真一
野手 信哉
収録物名
Shimane journal of medical science
9
1
開始ページ 21
終了ページ 28
収録物識別子
ISSN 03865959
EISSN 24332410
内容記述
抄録・要旨
To clarify whether prostaglandin synthesis is involved in the regulation of insulin release from isolated rat islets, we performed three different experiments. The direct effects of prostaglandin E_1 and prostacyclin on insulin release were investigated. Neither prostaglandin had any effect in the presence of low and high concentrations of glucose. Indomethacin, aspirin^<[○!R]> (acetylsalicylic acid) and flurbiprofen, inhibitors of cyclooxygenase, did not have a significant effect on insulin release evoked by glucose. Exogenous phospholipase A_2 purified from bee venom and melittin stimulated insulin release. A potent and selective inhibitor of phospholipase A_2,mepacrine, inhibited glucose-induced insulin release. The present work indicates that 1) cyclooxygenase does not participate early release of insulin from islet 2) activation of phospholipase A_2 might be involved in insulin stimulus-secretion coupling.
主題
Langerhans' islet
prostaglandins
insulin release
言語
英語
資源タイプ 紀要論文
出版者
Shimane Medical University
発行日 1985-11-01
出版タイプ Version of Record(出版社版。早期公開を含む)
アクセス権 オープンアクセス
関連情報
[NCID] AA00841586