Effects of Cyclophosphamide on Lymph Nodes and Pyroninophilic Cells

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m003000401003.pdf 1.57 MB エンバーゴ : 2015-10-13
タイトル
Effects of Cyclophosphamide on Lymph Nodes and Pyroninophilic Cells
著者
地土井 襄爾
山崎 正博
高垣 謙二
山本 昇壮
望月 輝三
稲田 修一
収録物名
Shimane journal of medical science
4
1
開始ページ 23
終了ページ 30
収録物識別子
ISSN 03865959
EISSN 24332410
内容記述
抄録・要旨
Cyclophosphamide was given intraperitoneally to guinea pigs in a dose of 10 mg/day for a period of 5 days and the histological changes were studied on the 1st,5th and 10th days after the administration. Changes in number of pyroninophilic cells due to DNCB sensitization were also studied. On the 1st day after discontinuation of Cyclophosphamide, the germinal centres, lymph follicles and paracortical areas of the lymph nodes all showed the same degree of cell component loss, but on the 10th day, only the germinal centres had been restored to their normal level, while the other sites showed a delay in recovery. The administration of Cyclophosphamide prior to DNCB sensitization resulted in a greater increase in pyroninophilic cells in the paracortical area of the regional lymph nodes than in the controls, between 7 to 13 days after sensitization. No increase was noted in the group that was given the drug after sensitization.Thus decrease in the lymph node component was accounted for by the B-cells which are susceptible to the effects of Cyclophosphamide, and the increase in pyroninophilic cells was attributed to this marked decrease in B-cells.
主題
Cyclophosphamide effects
lymph nodes
pyroninophilic cells
言語
英語
資源タイプ 紀要論文
出版者
Shimane Medical University
発行日 1980-06-01
出版タイプ Version of Record(出版社版。早期公開を含む)
アクセス権 オープンアクセス
関連情報
[NCID] AA00841586