| File | |
| Title |
酵素的塩基交換反応を利用したチアミンアナログの調製
|
| Title |
Enzymic Preparation of Thiamine Analogues by the Utilization of a Base-Exchange Reaction
|
| Title Transcription |
コウソテキ エンキ コウカン ハンノウ オ リヨウシタ チアミン アナログ ノ チョウセイ
|
| Creator |
Nakamura Toshiie
Fujita Keiji
|
| Source Title |
島根大学農学部研究報告
Bulletin of the Faculty of Agriculture, Shimane University
|
| Volume | 18 |
| Start Page | 188 |
| End Page | 192 |
| Journal Identifire |
ISSN 0370940X
|
| Descriptions |
Abstract
The enzymic preparation of thiamine analogues was examined. Thiaminase I catalyzes an exchange reaction of the thiazole moiety of thiamine with aniline, pyridine, cysteine etc., liberating 2-hydroxyalkyl-4-methyl-5-β-hydroxyethylthiazole. Ten kinds of（2-methyl -4-amino-5-pynmidinyl）methyl derivatives(Pm derivatives) were preparated by the uti lization of the base-exchange reaction of free or Sepharose 4B-immobilized thiaminase I. Pm derivatives isolated were Pm-thiophenol, Pm-o-aminothiophenol, Pm-benzoic acid, Pmaniline, Pm-pyridine, Pm-α-pycoline, Pm-nicotinamide, Pm-quinoline, Pm-pyperidine, and Pm-cysteine. The physicochemical parameters of these compounds were determined.
|
| Language |
jpn
|
| Resource Type | departmental bulletin paper |
| Publisher |
島根大学農学部
Shimane University, Faculty of Agriculture
|
| Date of Issued | 1984-12-20 |
| Access Rights | open access |
| Relation |
[NCID]
AN00108015
|
