number of downloads : ?
File
language
eng
Attribute
Case Report
Author
SUTOU, Ichiro
Description
We have reported three cases in which switching from hydromorphone to oxycodone provided effective analgesia for neuropathic pain caused by cancer. Case 1 was ovarian cancer, case 2 was lung cancer and case 3 was carcinoma of unknown origin. We diagnosed parts of the pain were neuropathic pain caused by lymph node metastasis or bone metastasis of cancer in flow chart of grading system for neuropathic pain diagnosis chart. There are few reports on the effect of hydromorphone on neuropathic pain, the efficacy of oxycodone has been reported in a comparison of hydromorphone-induced morphine and oxycodone. It has been suggested that different effects for neuropathic pain between hydromorphone and oxycodone are due to the activation of GIRK1/ KIR3 channels in the ventrolateral periaqueductal gray matter region. The activation mechanism induces antinociceptive effects by suppressing gammaaminobutyric acid release. In our experience, oxycodone seemed to have a better effect on neuropathic pain than hydromorphone. Therefore, we believe that early use of oxycodone for cancer pain, in which activation-mediated neuropathic pain is considered to predominate in clinical practice, is likely to provide effective pain relief and improve patients' QOL.
Subject
neuropathic pain
cancer pain
oxycodone
hydromorphone
Journal Title
Shimane Journal of Medical Science
Volume
38
Issue
3
Start Page
99
End Page
105
ISSN
03865959
ISSN(Online)
24332410
Published Date
2021-09
NCID
AA00841586
Publisher
Faculty of Medicine, Shimane University
Publisher Aalternative
島根大学医学部
NII Type
Departmental Bulletin Paper
Format
PDF
Rights
Faculty of Medicine, Shimane University
Text Version
出版社版
OAI-PMH Set
Faculty of Medicine