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eng
Author
Description
Brain-derived neurotrophic factor (BDNF) is expressed at high levels in the hippocampal dentate gyrus (DG), and decreased levels of BDNF have been implicated in the pathophysiology of schizophrenia (SCZ). We have previously reported that yokukansan (YKS), which is a traditional Japanese medicine, is effective for SCZ and promotes neurogenesis in the DG of Gunn rats, an animal model of SCZ. In this study, we investigated the effect of YKS on serum BDNF levels in Gunn rats. The results showed that YKS increased serum BDNF in this model, which may suggest that BDNF expression in the DG leads to increased neurogenesis. Our findings may help to explain the efficacy of YKS in treating SCZ.
Journal Title
Journal of Brain Science,
Volume
44
Start Page
34
End Page
41
ISSN
1341-5301
ISSN(Online)
2432-2512
Published Date
2014-12-30
DOI
Publisher
日本脳科学会
Publisher Transcription
ニホン ノウカガッカイ
Publisher Aalternative
Japan Brain Science society
NII Type
Journal Article
Format
PDF
Text Version
出版社版
Gyoseki ID
e26971
OAI-PMH Set
Faculty of Medicine
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