| File |
Dipeptidyl Peptidase-4: Potential Pathogenic Roles in Diabetic Complications and More
1.23 MB
エンバーゴ :
2020-01-19
|
| Title |
Dipeptidyl Peptidase-4: Potential Pathogenic Roles in Diabetic Complications and More
|
| Creator | |
| Source Title |
Shimane Journal of Medical Science
|
| Volume | 36 |
| Issue | 2-3 |
| Start Page | 33 |
| End Page | 40 |
| Journal Identifire |
ISSN 03865959
EISSN 24332410
|
| Descriptions |
Abstract
Both the disruption of endothelial homeostasis and tissue fibrosis are characteristics of diabetic complications. Accumulating evidence has revealed the significant role of vascular endothelial cells in tissue fibrogenesis via endothelial-mesenchymal transition （EndMT）.
We have recently focused on the overexpression of endothelial dipeptidyl peptidase （DPP）-4, a critical pathological feature of the molecular mechanisms of EndMT, and suggest that DPP-4 inhibitors have great therapeutic potential via their antifibrotic effects. However, the diverse pleiotropic effects of DPP-4, both its enzyme-dependent and enzyme-independent effects, can be detrimental in some cases. This review provides an update on the biology of DPP-4, a profibrotic molecule, in addition to a discussion of cancer biology. |
| Subjects |
fibrosis
microRNA
integrin
extracellular matrix
cancer
|
| Language |
eng
|
| Resource Type | departmental bulletin paper |
| Publisher |
Faculty of Medicine, Shimane University
島根大学医学部
|
| Date of Issued | 2019-12 |
| Rights |
Faculty of Medicine, Shimane University
|
| Publish Type | Version of Record |
| Access Rights | open access |
| Relation |
[NCID] AA00841586
|
