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language
eng
Author
Note, Shinya
Ohashi Miyoji
Wakayama, Yuji
Description
(1) The average daily excretion values in dehydroepiandrosterone (DHA), androsterone (A) and 11-deoxygenated 17-KS were very lower in children and the levels proved to become higher at onset of puberty, to reach the maximum in young adults and then to decrease gradually by aging. But the value of 11-oxygenated 17-KS, which were metabolized mainly from adrenal steroids, was not so much decreased with advancing age after young adulthood. The endogenous secretion of androgens, which contributes to the
accelerating of protein anabolic process in the body, appeared to be depressed at the senile stage.
(2) In patients with gastric ulcer of simple or multiple type, average daily excretion value of DHA, A and A+etiocholanolone (E) was decreased accompanying with the diminished value of A/E ratio and the abnormal findings were normalized after wound healing.In spite of decreased A excretion value, the elevation of DHA (%) was recognized in the group of reftactory ulcer type. A characteristic picture in patients with duodenal ulcer was found in the increase in total 17-OHCS with decreased DHA and A excretion values. These data indicate that a decrease in endogenous androgen secretion
may play an important part in the peptic ulcer formation.
Subject
urinary neutral 17-KS fractions
aging
peptic ulcer
Journal Title
Shimane journal of medical science
Volume
1
Start Page
49
End Page
61
ISSN
03865959
ISSN(Online)
24332410
Published Date
1977-12-01
NCID
AA00841586
Publisher Aalternative
Shimane Medical University
NII Type
Departmental Bulletin Paper
Format
PDF
Text Version
出版社版
OAI-PMH Set
Faculty of Medicine