ファイル情報(添付) |
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タイトル |
The Gut Microbiota Response to Electroconvulsive Therapy for Schizophrenia: A Prospective Cohort Study
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著者 | |
収録物名 |
Shimane Journal of Medical Science
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巻 | 41 |
号 | 3 |
開始ページ | 83 |
終了ページ | 91 |
収録物識別子 |
ISSN 03865959
EISSN 24332410
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内容記述 |
抄録・要旨
Although electroconvulsive therapy (ECT) is an effective treatment for schizophrenia, the treatment response rate is only approximately 50%. In addition, it is not clear what the optimal conditions are for maximizing ECT responsiveness. Meanwhile, an association between gut microbiota and the pathophysiology of schizophrenia has recently been reported. Therefore, we explored whether gut microbiota might predict the therapeutic efficacy of ECT. We examined the bacterial percentage of the gut microbiota of 11 patients with schizophrenia who received ECT treatment. Linear regression analyses showed that high Bifidobacterium and low Lactobacillus levels in stools before ECT were associated with a decrease in symptom severity, as measured by the Brief Psychiatric Rating Scale, after ECT. No bacteria showed significant changes in proportion before and after ECT. Our results suggest that Bifidobacterium and Lactobacillus levels could predict the responsiveness to ECT but not changes in the severity of schizophrenia.
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主題 |
ECT
gut microbiota
schizophrenia
Bifidobacterium
Lactobacillus
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言語 |
英語
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資源タイプ | 紀要論文 |
出版者 |
Faculty of Medicine, Shimane University
島根大学医学部
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発行日 | 2024-09 |
権利情報 |
Faculty of Medicine, Shimane University
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権利関係(リンク) | ![]() This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. |
出版タイプ | Version of Record(出版社版。早期公開を含む) |
アクセス権 | オープンアクセス |
関連情報 |
[NCID] AA00841586
[DOI] 10.51010/sjms.41.3_83
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