Mice with an Oncogenic HRAS Mutation are Resistant to High-Fat Diet-Induced Obesity and Exhibit Impaired Hepatic Energy Homeostasis

EBIOMEDICINE Volume 27 Page 138-150 published_at 2018-01
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Title
Mice with an Oncogenic HRAS Mutation are Resistant to High-Fat Diet-Induced Obesity and Exhibit Impaired Hepatic Energy Homeostasis
Creator
Oba Daiju
Inoue Shin-ichi
Miyagawa-Tomita Sachiko
Nakashima Yasumi
Niihori Tetsuya
Matsubara Yoichi
Aoki Yoko
Source Title
EBIOMEDICINE
Volume 27
Start Page 138
End Page 150
Journal Identifire
ISSN 2352-3964
Subjects
Costello syndrome; Hras G12S; Mitochondrial fatty acid oxidation; Diet-induced obesity; Cancer metabolism; ERK
Language
eng
Resource Type journal article
Publisher
ELSEVIER
Date of Issued 2018-01
Access Rights metadata only access
Relation
[DOI] 10.1016/j.ebiom.2017.11.029
[PMID] 29254681
Remark This work was supported by the Funding Program for the Next Generation of World-Leading Researchers (NEXT Program) from the Ministry of Education, Culture, Sports, Science and Technology of Japan to Y.A. (LS004), the Grants-in-Aid by the Practical Research Project for Rare/Intractable Diseases from the Japan Agency for Medical Research and Development, AMED to Y.A. (16eK0109021,17894363), by the Japan Society for the Promotion of Science (JSPS) KAKENHI Grant Number 26293241 and 16K15522 to Y.A., and by JSPS KAKENHI Grant Number 15K19598 to S.I.