Propofol induces a metabolic switch to glycolysis and cell death in a mitochondrial electron transport chain-dependent manner

PLOS ONE Volume 13 Issue 2 published_at 2018-02-15
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Title
Propofol induces a metabolic switch to glycolysis and cell death in a mitochondrial electron transport chain-dependent manner
Creator
Sumi Chisato
Okamoto Akihisa
Tanaka Hiromasa
Nishi Kenichiro
Kusunoki Munenori
Shoji Tomohiro
Uba Takeo
Matsuo Yoshiyuki
Adachi Takehiko
Hayashi Jun-Ichi
Takenaga Keizo
Hirota Kiichi
Source Title
PLOS ONE
Volume 13
Issue 2
Journal Identifire
ISSN 1932-6203
Language
eng
Resource Type journal article
Publisher
PUBLIC LIBRARY SCIENCE
Date of Issued 2018-02-15
Access Rights metadata only access
Relation
[DOI] 10.1371/journal.pone.0192796
[PMID] 29447230
Remark This work was supported by the Japan Society for the Promotion of Science KAKENHI, Grants #26670693 and #24592336 to K.H., #25462457 to K.N., and #15K15577 to T.A., and by a research grant from Katano Kai to K.H. and A.O. This work was supported by the research grant B from Kansai Medical University to A.O., the KMU consortium grant from Kansai Medical University to K.H. and the research grant from Katano Kai to A.O. and K.H. This work was supported by the Japanese Society of Anesthesiologists (JSA) Pitch Contest 2017 to C.S. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.