| Title |
Fibril formation and therapeutic targeting of amyloid-like structures in a yeast model of adenine accumulation
|
| Creator |
Laor Dana
Sade Dorin
Shaham-Niv Shira
Zaguri Dor
Gartner Myra
Basavalingappa Vasantha
Raveh Avi
Pichinuk Edward
Engei Hamutal
Lwasaki Keita
Noothalapati Hemanth
Gazit Ehud
|
| Source Title |
NATURE COMMUNICATIONS
|
| Volume | 10 |
| Journal Identifire |
ISSN 2041-1723
|
| Language |
eng
|
| Resource Type | journal article |
| Publisher |
NATURE PUBLISHING GROUP
|
| Date of Issued | 2019-01-8 |
| Access Rights | metadata only access |
| Relation |
[DOI] 10.1038/s41467-018-07966-5
[PMID] 30622276
|
| Remark | We thank A. Brandis for GC-MS analysis, E. Haimov and B. Redko for LC-MS analysis, A. Lichtenstein for confocal microscopy analysis, O. Sagi-Assif for the fluorescence-activated cell sorting analysis, B. Lifshitz and L. Gershon for assistance with plasmids cloning, K. Simpson-Lavy for assistance with the Hsp104 experiments, T. Guterman for assistance in Fig. 1d, S. Rencus-Lazar for proofreading the article. We thank A. Parket and members of the Gazit, Adler-Abramovich, and Kupiec laboratories for helpful discussions. This work was supported by the Israel Science Foundation (Grant no. 802/15; E.G.) and by the Adelis Forever Foundation (E.G.). This research was a collaboration with the BCDD, funded by Len Blavatnik and the Blavatnik Family Foundation. This work is dedicated to the memory of Prof. Susan L. Lindquist (1949-2016), a pioneer and visionary in the establishment of yeast models of neurodegenerative amyloid disorders and their therapeutic treatment. |
