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Tandem Flavin-Iodine-Catalyzed Aerobic Oxidative Sulfenylation of Imidazo[1,2-a]Pyridines with Thiols
1.57 MB
エンバーゴ :
2020-03-18
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| Title |
Tandem Flavin-Iodine-Catalyzed Aerobic Oxidative Sulfenylation of Imidazo[1,2-a]Pyridines with Thiols
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| Creator |
Demizu Ryuta
Ohkado Ryoma
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| Source Title |
The Journal of Organic Chemistry
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| Volume | 83 |
| Issue | 19 |
| Start Page | 12291 |
| End Page | 12296 |
| Journal Identifire |
ISSN 0022-3263
EISSN 1520-6904
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| Descriptions |
Other
A green, aerobic sulfenylation of imidazo[ 1,2-a]pyridines was performed using thiols, a flavinand- iodine dual catalytic system, and environmentally benign molecular oxygen as the only sacrificial reagent. The dual metal-free catalysts smoothly promote a unique stepwise tandem process, beginning with the aerobic oxidation of a thiol to afford a disulfide that is utilized in the oxidative sulfenylation of the imidazo[1,2-a]pyridine. This process has afforded diverse 3-sulfenylimidazo[1,2-a]pyridines of biological interest, and is environmentally friendly as benign H2O is the only by-product.
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| Subjects |
Disulfides
Reagents
Flavins
Thiols
Catalysts
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| Language |
eng
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| Resource Type | journal article |
| Publisher |
American Chemical Society
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| Date of Issued | 2018-10-1 |
| Rights |
https://s100.copyright.com/AppDispatchServlet?startPage=12291&pageCount=6©right=American+Chemical+Society&author=Hiroki+Iida%2C+Ryuta+Demizu%2C+Ryoma+Ohkado&orderBeanReset=true&imprint=American+Chemical+Society&volumeNum=83&issueNum=19&contentID=acs.joc.8b01878&title=Tandem+Flavin-Iodine-Catalyzed+Aerobic+Oxidative+Sulfenylation+of+Imidazo%5B1%2C2-a%5DPyridines+with+Thiols&numPages=6&pa=&issn=0022-3263&publisherName=acs&publication=joceah&rpt=n&endPage=12296&publicationDate=October+2018
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| Publish Type | Accepted Manuscript |
| Access Rights | open access |
| Relation |
[DOI]
10.1021/acs.joc.8b01878
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| Remark | J. Org. Chem. 2018, 83, 19, 12291-12296 |
