Title |
Celiac disease in non-clinical populations of Japan
|
Creator |
Fukuyama Chika
Izumi Daisuke
Ishikawa Nahoko
Oka Akihiko
Mishiro Tomoko
|
Source Title |
Journal of Gastroenterology
|
Volume | 53 |
Issue | 2 |
Start Page | 208 |
End Page | 214 |
Journal Identifire |
ISSN 0944-1174
EISSN 1435-5922
|
Descriptions |
Background
Celiac disease is a chronic autoimmune enteropathy caused by gluten ingestion. While its prevalence in Western countries is reported to be as high as 1%, the prevalence has not been evaluated in a large-scale study of a Japanese population. The aim of our study was to clarify the possible presence of celiac disease in a Japanese non-clinical population as well as in patients showing symptoms suggestive of the disease. Methods Serum samples were collected from 2008 non-clinical adults and 47 patients with chronic unexplained abdominal symptoms between April 2014 and June 2016. The anti-tissue transglutaminase (TTG) immunoglobulin A antibody titer was determined as a screening test for celiac disease in all subjects, and individuals with a value of >2 U/mL subsequently underwent testing for the presence of serum endomysial IgA antibody (EMA) as confirmation. Those testing positive for EMA or with a high concentration (>10 U/mL) of TTG were further investigated by histopathological examinations of duodenal mucosal biopsy specimens and HLA typing tests. Results Of the 2008 non-clinical adults from whom serum samples were collected, 161 tested positive for TTG, and all tested negative for EMA. Four subjects who had a high TTG titer were invited to undergo confirmatory testing, and the histopathological results confirmed the presence of celiac disease in only a single case (0.05%). Of the 47 symptomatic patients, one (2.1%) was found to have a high TTG titer and was diagnosed with celiac disease based on duodenal histopathological findings. Conclusion The presence of celiac disease in a non-clinical Japanese population was low at 0.05% and was rarely found in patients with unexplained chronic abdominal symptoms. |
Language |
eng
|
Resource Type | journal article |
Publisher |
シュプリンガー・ジャパン(株)
|
Date of Issued | 2017-4-7 |
Publish Type | Version of Record |
Access Rights | metadata only access |
Relation |
[DOI] 10.1007/s00535-017-1339-9
|
Remark | 日本消化器病学会 |