Elevated serum pentosidine and decreased serum IGF-I levels are associated with loss of muscle mass in postmenopausal women with type 2 diabetes mellitus

Experimental and clinical endocrinology & diabetes Volume 124 Issue 3 Page 163-166 published_at 2016-03
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Title
Elevated serum pentosidine and decreased serum IGF-I levels are associated with loss of muscle mass in postmenopausal women with type 2 diabetes mellitus
Creator
Tanaka Ken-ichiro
Source Title
Experimental and clinical endocrinology & diabetes
Volume 124
Issue 3
Start Page 163
End Page 166
Journal Identifire
ISSN 09477349
Descriptions
Advanced glycation end-products (AGEs) play important roles in the progression of diabetic complications. Although sarcopenia is recently recognized as another complication associated with diabetes mellitus, its mechanism still remains unclear. In this study, we investigated the relationship between serum levels of pentosidine, which is one of AGEs, and insulin-like growth factor-I (IGF-I) vs. skeletal muscle mass by whole body dual-energy x-ray absorptiometry in 133 postmenopausal women with type 2 diabetes. Relative skeletal muscle mass index (RSMI) was calculated by following formula; appendicular skeletal muscle mass divided by height in meters squared. Simple correlation analyses showed that serum pentosidine levels were significantly and negatively correlated with muscle mass of legs (r=-0.21, p=0.017) and RSMI (r=-0.18, p=0.022), and that IGF-I was significantly and positively correlated with muscle mass of arms and legs (r=0.23, p=0.008 and r=0.30, p=0.001, respectively) as well as RSMI (r=0.20, p=0.022). Moreover, after adjusting for age, duration of diabetes, serum creatinine, HbA1c, and IGF-I, pentosidine was significantly and negatively associated with RSMI (β=-0.27, p=0.018) and marginally with muscle mass of legs (β=-0.18, p=0.071). The associations between IGF-I and indices of muscle mass such as arms, legs and RSMI were still significant after additional adjustment for pentosidine (p=0.016, 0.019 and 0.021, respectively). These findings indicate that increased serum pentosidine and decreased IGF-I are independent risk factors for loss of muscle mass in postmenopausal women with type 2 diabetes.
Subjects
pentosidine ( Other)
skeletal muscle mass ( Other)
sarcopenia ( Other)
diabetes mellitus ( Other)
IGF-I ( Other)
Language
eng
Resource Type journal article
Publisher
Thieme
Date of Issued 2016-03
Rights
© Georg Thieme Verlag KG Stuttgart・New York
Publish Type Accepted Manuscript
Access Rights open access
Relation
[DOI] 10.1055/s-0035-1565103
[PMID] 26575120