| File | |
| Title |
インターフェロンアルファ療法後多臓器不全にて死亡した慢性骨髄性白血病の剖検例
|
| Title |
A case of Multi-organ Failure Associated with Interferone-α (IFN-α) Therapy for Chronic Myelocytic Leukemia (CML)
|
| Title Transcription |
インターフェロン アルファ リョウホウゴ タゾウキ フゼン ニテ シボウ シタ マンセイ コツズイセイ ハッケツビョウ ノ ボウケンレイ
|
| Creator |
Doi Takashi
Torii Ikuko
Morikawa Shigeru
|
| Source Title |
島根医科大学紀要
Bulletin of Shimane Medical University
|
| Volume | 21 |
| Start Page | 45 |
| End Page | 50 |
| Journal Identifire |
ISSN 03879097
|
| Descriptions |
Interferone-α is used recently in the treatment of hematologic malignancies as well as viral hepatitis. Occurrences of various adverse effects associated with IFN have been reported increasingly. We report here in a case of patient who developed diverse clinical symptoms in various organs such as heart, liver, kidney following long-term IFN therapy for chronic myelocytic leukemia. The autopsy revealed the pathological changes in various tissues such as the heart muscles, the renal glomeruli and the skeletal muscles, which were confirmed by transmitted electron microscopy. The possible roles of IFN-α in those tissue damages are discussed.
|
| Subjects | |
| Language |
jpn
|
| Resource Type | departmental bulletin paper |
| Publisher |
島根医科大学
|
| Date of Issued | 1998-12-01 |
| Publish Type | Version of Record |
| Access Rights | open access |
| Relation |
[NCID] AN00107602
|
