ダウンロード数 : ?
ファイル
言語
英語
著者
Juman, Sachiko School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University
橋本 道男
片倉 賢紀
Inoue, Takayuki Department of Environmental Physiology, Shimane University Faculty of Medicine
Arita, Makoto Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo
Miki, Tomohiro School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women’s University
内容記述(抄録等)
Natural killer (NK) cells have many functional activities, including cytotoxicity and the capacity to produce cytokines and chemokines. NK cell activity is regulated partly by eicosanoids, which are produced from arachidonic acid (ARA) and eicosapentaenoic (EPA) acid. In this study, we investigated the effects of long-term therapy with ARA or docosahexaenoic acid (DHA) on the cytotoxic effects of the NK cells of young rats, which were fed on a nonfish oil diet for two generations. Control oil, ARA (240 mg/kg BW/day) or DHA (240 mg/kg BW/day) were orally administrated to the rats for 13 weeks before determining the cytotoxic activity of NK cells from the spleen against YAC-1 mouse lymphoma cell line, as well as the plasma levels of docosanoids or eicosanoids and inflammatory cytokines. Long-term ARA administration significantly suppressed the cytotoxic activity of NK cells. Moreover, ARA administration significantly increased the plasma levels of ARA, prostaglandin (PG) E2, and PGD2. However, DHA administration did not produce any different effects compared with those in the control rats. Furthermore, the inflammatory cytokine levels were not affected by the administration of ARA or DHA. These results suggest that long-term ARA administration has an inhibitory effect on the tumor cytotoxicity of NK cells in rat spleen lymphocytes owing to the enhanced synthesis of PGE2 and PGD2 from ARA because of the elevated plasma ARA levels in young rats.
主題
natural killer cell
polyunsaturated fatty acid
prostaglandin E2
prostaglandin D2
eicosanoids
掲載誌名
Nutrients
5
6
開始ページ
1949
終了ページ
1961
ISSN
2072-6643
ISSN(Online)
2072-6643
発行日
2013-5-29
DOI
PubMed ID
出版者
MDPI Publishing
資料タイプ
学術雑誌論文
ファイル形式
PDF
著者版/出版社版
出版社版
業績ID
e21599
部局
医学部
このエントリーをはてなブックマークに追加