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ファイル
言語
英語
属性
原著論文
著者
須谷 顕尚
Kosaka Shinji
原田 祐治
神田 響
久良木 隆繁
内容記述(抄録等)
Pleomorphic carcinoma(PC) is a rare tumor that usually has an aggressive clinical course and a poor  prognosis. We investigated the hypothesis that PC overexpresses angiogenic factors. Furthermore, we compared rates of expression of angiogenic factors in PC and adenocarcinoma(AD) of the lung. We collected each 11 cases of PC and AD in which the patients underwent either a lung resection or at autopsy. We immunohistochemically examined the expression of angiogenic factors. Vascular endothelial growth factor(VEGF) and basic-fibroblast growth factor were expressed in many cases of both PC and AD, and there were no significant differences between the
two groups. However, the expression of cyclooxygenase(COX)-2 and hypoxia inducible factor-1α, and the microvessel density, were significantly greater in PC than in AD. These findings suggest that PC was associated with increased angiogenesis and that the
tumor tissue was in a hypoxic state. 
掲載誌名
Shimane journal of medical science
28
2
開始ページ
75
終了ページ
84
ISSN
03865959
ISSN(Online)
24332410
発行日
2012-02-01
NCID
AA00841586
出版者別表記
Shimane University Faculty of Medicine
資料タイプ
紀要論文
ファイル形式
PDF
著者版/出版社版
出版社版
部局
医学部
備考
http://ci.nii.ac.jp/vol_issue/nels/AA00841586_jp.html
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