Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index

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言語	英語
著者	Wen Wanqing Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA, Zheng Wei Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA, Okada Yukinori Laboratory for Statistical Analysis, Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan, Takeuchi Fumihiko Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan, Tabara Yasuharu Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan, Hwang Joo-Yeon Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea, Dorajoo Rajkumar Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore, Department of Genomics of Common Disease, School of Public Health, Imperial College London, Hammersmith Hospital, London, UK, Li Huaixing Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China, Tsai Fuu-Jen School of Chinese Medicine, Department of Medical Genetics, Department of Health and Nutrition Biotechnology, Asia University, Taichung, Taiwan, Yang Xiaobo Department of Occupational Health and Environmental Health, School of Public Health, Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi, China, He Jiang Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA, Wu Ying Department of Genetics, University of North Carolina, Chapel Hill, NC, USA, He Meian Department of Occupational and Environmental Health and the Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China, Zhang Yi State Key Laboratory of Medical Genetics, Shanghai Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, Shanghai Institute of Hypertension, Shanghai, China, Liang Jun Department of Endocrinology, Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical College, Affiliated Hospital of Southeast University, Xuzhou, Jiangsu 221009, China, Guo Xiuqing Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Institute for Translational Genomics and Populations Sciences, Torrance, CA, USA, Sheu Wayne Huey-Herng Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan, National Defense Medical Center, College of Medicine, Taipei, Taiwan, School of Medicine, National Yang-Ming University, Taipei, Taiwan, Delahanty Ryan Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA, Guo Xingyi Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA, Kubo Michiaki Laboratory for Genotyping Development, Yamamoto Ken Department of Molecular Genetics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan, Ohkubo Takayoshi Department of Planning for Drug Development and Clinical Evaluation, Tohoku University Graduate School of Pharmaceutical Sciences, Sendai, Japan, Department of Health Science, Shiga University of Medical Science, Otsu, Japan, Go Min Jin Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea, Liu Jian Jun Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore, Gan Wei Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China, Chen Ching-Chu School of Chinese Medicine, Division of Endocrinology and Metabolism, Department of Medicine, China Medical University Hospital, Taichung, Taiwan, Gao Yong Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi, China, College of General Practice, Guangxi Medical University, Nanning, Guangxi, China, Li Shengxu Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA, Lee Nanette R. USC-Office of Population Studies Foundation, Inc., University of San Carlos, Cebu, Philippines, Wu Chen State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, Zhou Xueya Bioinformatics Division, Tsinghua National Laboratory of Information Science and Technology, Beijing, China Song Huaidong State Key Laboratory of Medical Genomics, Ruijin Hospital, Molecular Medical Center, Shanghai Institute of Endocrinology, Shanghai Jiao Tong University School of Medicine, Shanghai, China, Yao Jie Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Institute for Translational Genomics and Populations Sciences, Torrance, CA, USA, Lee I-Te Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan, Department of Medicine, Chung-Shan Medical University, Taichung, Taiwan, Long Jirong Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA, Tsunoda Tatsuhiko Laboratory for Medical Science Mathematics, Akiyama Koichi Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan, Takashima Naoyuki Department of Health Science, Shiga University of Medical Science, Otsu, Japan, Cho Yoon Shin Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea, Department of Biomedical Science, Hallym University, Gangwon-do, Republic of Korea, Ong Rick T. H. Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore, NUS Graduate School for Integrative Science and Engineering, Centre for Molecular Epidemiology, National University of Singapore, Singapore, Singapore Lu Ling Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China, Chen Chien-Hsiun School of Chinese Medicine, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan, Tan Aihua Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi, China, Rice Treva K. Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA, Adair Linda S. Department of Nutrition, University of North Carolina, Chapel Hill, NC, USA Gui Lixuan Department of Occupational and Environmental Health and the Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China, Allison Matthew Department of Family and Preventive Medicine, Lee Wen-Jane Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan, Department of Social Work, Tunghai University, Taichung, Taiwan, Cai Qiuyin Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA, 磯村実 Umemura Satoshi Department of Medical Science and Cardiorenal Medicine, Yokohama City University School of Medicine, Yokohama, Japan, Kim Young Jin Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea, Seielstad Mark Institute of Human Genetics, University of California, San Francisco, USA, Hixson James Human Genetics Center, University of Texas School of Public Health, Houston, TX, USA, Xiang Yong-Bing Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Isono Masato Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan, Kim Bong-Jo Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea, Sim Xueling Centre for Molecular Epidemiology, National University of Singapore, Singapore, Singapore Lu Wei Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China, 並河徹 Lee Juyoung Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea, Lim Wei-Yen Saw Swee Hock School of Public Health, Gao Yu-Tang Department of Epidemiology, Shanghai Cancer Institute, Shanghai Jiao Tong University, Shanghai, China, Takayanagi Ryoichi Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, Kang Dae-Hee Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Wong Tien Yin Department of Ophthalmology, Yong Loo Lin School of Medicine, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore, Hsiung ChaoAgnes Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan, Wu I-Chien Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan, Juang Jyh-Ming Jimmy Cardiovascular Center and Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan Shi Jiajun Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA, Choi Bo Youl Department of Preventive Medicine, College of Medicine, Hanyang University, Seoul, Republic of Korea, Aung Tin Department of Ophthalmology, Yong Loo Lin School of Medicine, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore, Hu Frank Department of Epidemiology, Department of Nutrition, Harvard University School of Public Health, Boston, MA, USA, Kim Mi Kyung Department of Preventive Medicine, College of Medicine, Hanyang University, Seoul, Republic of Korea, Lim WeiYen Saw Swee Hock School of Public Health, Wang Tzung-Dao Cardiovascular Center and Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan Shin Min-Ho Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea, Lee Jeannette Saw Swee Hock School of Public Health, Ji Bu-Tian Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA Lee Young-Hoon Department of Preventive Medicine & Institute of Wonkwang Medical Science, Wonkwang University College of Medicine, Iksan, Republic of Korea Young Terri L. Department of Ophthalmology, Duke University Medical Center, Durham, NC, USA, Division of Neuroscience, Duke-National University of Singapore Graduate Medical School, Singapore, Singapore Shin Dong Hoon Department of Preventive Medicine, Keimyung University School of Medicine, Daegu, Republic of Korea Chun Byung-Yeol Department of Preventive Medicine, School of Medicine, and Health Promotion Research Center, Kyungpook National University, Daegu, Republic of Korea, Cho Myeong-Chan National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea, Han Bok-Ghee Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea, Hwu Chii-Min School of Medicine, National Yang-Ming University, Taipei, Taiwan, Section of Endocrinology and Metabolism, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Assimes Themistocles L. Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA, Absher Devin HudsonAlpha Institute for Biotechnology, Huntsville, AL, USA, Yan Xiaofei Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Institute for Translational Genomics and Populations Sciences, Torrance, CA, USA Kim Eric Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Institute for Translational Genomics and Populations Sciences, Torrance, CA, USA, Kuo Jane Z. NShiley Eye Center, Department of Ophthalmology, University of California at San Diego, La Jolla, CA, USA, Kwon Soonil Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Institute for Translational Genomics and Populations Sciences, Torrance, CA, USA, Taylor Kent D. Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Institute for Translational Genomics and Populations Sciences, Torrance, CA, USA Chen Yii-Der I. Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Institute for Translational Genomics and Populations Sciences, Torrance, CA, USA Rotter Jerome I. Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Institute for Translational Genomics and Populations Sciences, Torrance, CA, USA Qi Lu Department of Nutrition, Harvard University School of Public Health, Boston, MA, USA, Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, USA Zhu Dingliang State Key Laboratory of Medical Genetics, Shanghai Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, Shanghai Institute of Hypertension, Shanghai, China Wu Tangchun Department of Occupational and Environmental Health and the Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China Mohlke Karen L. Department of Genetics, University of North Carolina, Chapel Hill, NC, USA Gu Dongfeng https://academic.oup.com/hmg/article/23/20/5492/2900672#:~:text=Department%20of%20Evidence%20Based%20Medicine%2C%20Fuwai%20Hospital%2C%20Chinese%20Academy%20of%20Medical%20Sciences%20and%20Peking%20Union%20Medical%20College%2C%20and%20National%20Center%20for%20Cardiovascular%20Diseases%2C%20Beijing%2C%20China Mo Zengnan Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi, China, Institute of Urology and Nephrology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China Wu Jer-Yuarn School of Chinese Medicine, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan Lin Xu Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China Miki Tetsuro Department of Geriatric Medicine, Ehime University Graduate School of Medicine, Toon, Japan Tai E. Shyong Saw Swee Hock School of Public Health, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, and National University Health System, Singapore, Singapore Duke–National University of Singapore Graduate Medical School, Singapore, Singapore Lee Jong-Young Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea Kato Norihiro Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan Shu Xiao-Ou Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA Tanaka Toshihiro Laboratory for Cardiovascular Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan, Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan, Division of Disease Diversity, Bioresource Research Center, Tokyo Medical and Dental University, Tokyo, Japan
掲載誌名	HUMAN MOLECULAR GENETICS
巻	23
号	20
開始ページ	5492
終了ページ	5504
ISSN	0964-6906
ISSN（Online）	1460-2083
発行日	2014-10-15
DOI	10.1093/hmg/ddu248
PubMed ID	24861553
出版者	OXFORD UNIV PRESS
資料タイプ	学術雑誌論文
部局	医学部
備考	This work was supported by the sources listed below. The funding information provided below pertains to the participating studies that contributed summary statistics to this meta-analysis. The funders of the original studies had no role in study design, data collection and analysis, decision to publish or preparation of this manuscript. The SGWAS was supported in part by US National Institutes of Health grants R37CA070867 (to W.Z.), R01CA082729 (to X.-O. S.), R01CA124558 (to W.Z.), R01CA148667 (to W.Z.) and R01CA122364 (G.Y.), as well as Ingram Professorship and Research Reward funds from the Vanderbilt University School of Medicine. Participating studies (grant support) in the Shanghai Genome-Wide Association Studies (SGWAS) are as follows: Shanghai Women's Health Study (R37CA070867 to W.Z.), Shanghai Men's Health Study (R01CA082729 to X.-O.S.), Shanghai Breast Cancer Study (R01CA064277 to X.-O.S.) and Shanghai Endometrial Cancer Study (R01CA092585 to X.-O.S.). We thank Regina Courtney for DNA preparation and Jing He for data processing and analyses. The JMGP was supported by Grants for Scientific Research (Priority Areas Medical Genome Science (Millennium Genome Project) and Applied Genomics, Leading Project for Personalized Medicine, and Scientific Research 20390185, 21390099, 19659163, 16790336, 12204008, 15790293, 16590433, 17790381, 17790381, 18390192, 18590265, 18590587, 18590811, 19590929, 19650188, 19790423, 17390186, 20390184 and 21390223) from the Ministry of Education, Culture, Sports, Science, and Technology, Japan; a Grants-in-Aid [H15-Longevity005, H17-longevity-003, H16-kenko-001, H18-longevity (kokusai), H11-longevity-020, H17-Kenkou-007, H17-pharmaco-common003, H18-Junkankitou (Seishuu)-Ippan-012 and H20-Junkankitou (Seishuu)-Ippan-009, 013] from the Ministry of Health, Labor and Welfare, Health and Labor Sciences Research Grants, Japan; a Science and Technology Incubation Program in Advanced Regions, Japan Science and Technology Agency; a Grants-in-Aid from the Japan Society for the Promotion of Science (JSPS) fellows (16.54041, 18.54042, 19.7152, 20.7198, 20.7477 and 20.54043), Tokyo, Japan; Health Science Research Grants and Medical Technology Evaluation Research Grants from the Ministry of Health, Labor and Welfare, Japan; the Japan Atherosclerosis Prevention Fund; the Uehara Memorial Foundation; the Takeda Medical Research Foundation; and the Japan Research Foundation for Clinical Pharmacology. The KARE project was supported by a grant from the Korea Center for Disease Control and Prevention (4845-301, 4851-302, 4851-307), and intramural grant from the Korea National Institute of Health (2012-N73002-00). The 5P2 and SiMES were supported by the Singapore Ministry of Health's National Medical Research Council under its Individual Research Grant funding scheme, the Singapore National Research Foundation under its Clinician Scientist Award and Singapore Translational Research Investigator Award funding schemes, which are administered by the Singapore Ministry of Health's National Medical Research Council and the Singapore Biomedical Research Council (BMRC) individual research grant funding scheme. The NHAPC study is supported by research grants including the National High Technology Research and Development Program (2009AA022704), Knowledge Innovation Program (KSCX2-EW-R-10), the National Natural Science Foundation of China (30930081, 81021002, 81170734) and the National Key Basic Research Program of China (2012CB524900).; GenSalt is supported by research grants (U01HL072507, R01HL087263 and R01HL090682) from the National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD. The CLHNS was supported by National Institutes of Health grants DK078150, TW05596, HL085144 and TW008288 and pilot funds from RR20649, E510126 and DK56350. We thank the Office of Population Studies Foundation research and data collection teams for the Cebu Longitudinal Health and Nutrition Survey. The CRC was supported by grants from the National Heart, Lung, and Blood Institute (HL071981), the National Institute of Diabetes and Digestive and Kidney Diseases (DK091718 and DK078616), the Boston Obesity Nutrition Research Center (DK46200) and United States Israel Binational Science Foundation Grant 2011036. The MESA and MESA SHARe project are conducted and supported by contracts N01-HC-95159 through N01-HC-95169 and RR-024156 from the National Heart, Lung, and Blood Institute (NHLBI). Funding for MESA SHARe genotyping was provided by NHLBI Contract N02-HL-6-4278. The authors thank the participants of the MESA study, the Coordinating Center, MESA investigators and study staff for their valuable contributions. A full list of participating MESA investigators and institutions can be found at http://www. mesa-nhlbi.org. The TAICHI Metabochip study was supported by NHLBI grant HL087647. Financial support for HALST was through grants from the National Health Research Institutes (PH-100-SP-01). The SAPPHERe was supported by grants from the National Health Research Institutes (BS-094-PP-01 & PH-100-PP-03). The TCAGEN was partially supported by grants NTUH.98-N1266, NTUH100-N1775, NTUH101-N2010, NTUH101-N, VN101-04 and NTUH 101-S1784 from National Taiwan University Hospital, NSC 96-2314-B-002-152 and NSC 101-2325-002-078. The TACT was supported by grants from the National Science Council of Taiwan (NSC96-2314-B-002-151, NSC-982314-B-002-122-MY2 and NSC 100-2314-B-002-115). The Taiwan Dragon and TACD were supported by grants from the National Science Council (NSC 98-2314-B-075A-002-MY3) and Taichung Veterans General Hospital, Taichung, Taiwan (TCVGH-1013001 C; TCVGH-1013002D). The Taiwan Genome Wide Association Study was supported by the Academia Sinica Genomic Medicine Multicenter Study (Academia Sinica 40-05-GMM) and Search and build the biosignatures for type 2 diabetes complications in the Han Chinese population (Academia Sinica 23-2 h), Academia Sinica, Taiwan, and the National Center for Genome Medicine at Academia Sinica (NC GM, NSC-101-2319-B-001-001) of the National Core Facility Program for Biotechnology (NCFPB) and the Translational Resource Center for Genomic Medicine (TRC, NSC-101-2325-B-001-035) of the National Research Program for Biopharmaceuticals (NRPB), National Science Council, Taiwan.