ダウンロード数 : 105

公開日 : 2023-11-16
1.37 MB

著者
宮地 葵
秋保 美月
真子 卓也
永野 聖
内容記述(抄録等)
Qualitative changes in the extracellular matrix have been reported in thickened ligamentum flavum (LF) in lumbar spinal canal stenosis (LSCS); however, no detailed quantitative reports are available to date. Degenerated and undegenerated LF were collected from patients who underwent decompression surgery for LSCS and lumbar disc herniation, respectively. Three cylindrical samples of 2.5 mm diameter were cut from one LF specimen, completely solubilized, and quantified glycosaminoglycan (GAG), collagen (COL), and elastin. The amounts of GAG, COL, and elastin in the LSCS group were significantly higher than those in the control group. Although the GAG was originally present only in trace amounts, GAG proportion, standardized by dry weight, was the highest increase rate. Besides component analysis, histologic analysis showed intraligamentous chondrometaplasia in the caudal portion of the degenerated LF. Increased GAG in LF may be a new therapeutic target in LSCS.
主題
lumbar spinal canal stenosis
ligamentum flavum
glycosaminoglycan
collagen, elastin
掲載誌情報
Shimane Journal of Medical Science 40 ( 1-2 ), 1 - 8 , 2023-06
出版者
Faculty of Medicine, Shimane University
権利関係
Faculty of Medicine, Shimane University
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