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ファイル
言語
英語
属性
Review
著者
内容記述(抄録等)
The genome is carried by the complete linear sequence of DNA nucleotides packaged into all the chromosomes. During interphase, the chromosomes are extended and much of their chromatin exist as long threads while also maintaining specific three-dimensional architectures in the nuclear space. These interphase chromosomes are organized into multiscale three-dimensional structures, including chromosome territories, A/B compartments, topologically associating domains, and chromatin loops, that extend over a wide range of genomic distances, providing connections, for instance, between enhancers and promoters. This hierarchically organized genomic architecture is crucial for the regulation of gene transcription, which in turn is essential for the development and maintenance of various biological processes. This article reviews various aspects of spatial genome organization and their functions in gene expression and neural development. Furthermore, dysregulation of spatial genome organization in disease states, and the growing interest in new technologies to manipulate chromatin architecture are also discussed.
主題
central nervous system
development
disease
3D genome
chromatin
掲載誌名
Shimane Journal of Medical Science
39
3
開始ページ
77
終了ページ
93
ISSN
03865959
ISSN(Online)
24332410
発行日
2022-09
NCID
AA00841586
DOI
出版者
Faculty of Medicine, Shimane University
出版者別表記
島根大学医学部
資料タイプ
紀要論文
ファイル形式
PDF
権利関係
Faculty of Medicine, Shimane University
権利関係(リンク)
著者版/出版社版
出版社版
部局
医学部
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