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ファイル
言語
英語
属性
Review
著者
佐貫 毅
大内 佐智子
川島 耕作 医学部内科学講座内科学第二
石原 俊治 医学部内科学講座内科学第二
内容記述(抄録等)
Chronic diarrhea is a symptom frequently noted in patients with various diseases. In addition to organic conditions, such as inflammatory bowel and neoplastic diseases, functional diseases including irritable bowel syndrome are important etiological factors related to chronic diarrhea. According to recent reports, approximately one-third of cases with suspected irritable bowel syndrome are actually diagnosed as bile acid diarrhea, which is characterized by decreased absorption of bile acids from the terminal ileum as well as their hepatic overproduction. Clinical signs and symptoms of bile acid diarrhea do not differ from those of other diseases complicated with chronic diarrhea, and reliable laboratory tests for proper diagnosis are not available in Japan. On the other hand, effective treatment is possible with oral administration of bile acid sequestrants. Therefore, in cases of irritable bowel syndrome with diarrhea and functional diarrhea, the possibility of bile acid diarrhea should always be considered, with a treatment trial with bile acid sequestrants discussed herein as an option.
主題
diarrhea
etiology
colestimide
bile acid
ileum
掲載誌名
Shimane Journal of Medical Science
38
3
開始ページ
89
終了ページ
97
ISSN
03865959
ISSN(Online)
24332410
発行日
2021-09
NCID
AA00841586
DOI
DOI(SelfDOI)
出版者
Faculty of Medicine, Shimane University
出版者別表記
島根大学医学部
資料タイプ
紀要論文
ファイル形式
PDF
権利関係
Faculty of Medicine, Shimane University
権利関係(リンク)
著者版/出版社版
出版社版
部局
医学部
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