タイトルヨミ | ヒト ノ セイジョウ オヨビ ビョウテキ フクジン ソシキ ニ オケル プレネグネノロン カラ Δ^<16>-C_<19> ステロイド ノ セイセイ
|
日本語以外のタイトル | Biosynthesis of Δ^<16>-C_<19> Steroids from Pregnenolone by Human Normal and Abnormal Adrenal Tissues
|
ファイル | |
言語 |
日本語
|
著者 |
仲田 富士徳
小原 ひろみ
常角 幸恵
|
内容記述(抄録等) | To study the formation of 16-unsaturated C_<19> steroids from pregnenolone by human adrenal in vitro, normal and abnormal adrenal tissues were incubated with ^3H- or ^<14>C- labelled pregnenolone and the metabolites were analyzed.
1) Normal tissue was obtained from a 51 year-old woman with pyonephrosis, and the tissue was found to have produced androst-16-en-3β-ol, in addition to cortisol and many other steroids which are well known to be biosynthesized. 2) The tissue obtained from a 19 year-old woman with Cushing's syndrome metabolized pregnenolone mainly to 11-hydroxysteroids, and to several other compounds in small quantities. Dehydroepiandrosterone and androst-16-ene derivatives were not produced in detectable quantities. 3) Adenoma tissues were obtained from a 5 year-old boy with Child-Hercules and a 44 year-old woman with virilism. The former's tissue produced androst-16-en-3β-ol while the latter's andosta-5,16-dien-3β-ol. Neither 11-hydroxysteroids nor dehydroepiandrosterone was formed by the latter tissue in detectable quantities. |
主題 | Δ^<16>-C_<19>ステロイド
副腎
Δ^<16>-C_<19> Steroid
adrenal
|
掲載誌名 |
島根医科大学紀要
|
巻 | 1
|
開始ページ | 67
|
終了ページ | 76
|
ISSN | 03879097
|
発行日 | 1978-12-01
|
NCID | AN00107602
|
出版者 | 島根医科大学
|
資料タイプ |
紀要論文
|
ファイル形式 |
PDF
|
著者版/出版社版 |
出版社版
|
部局 |
医学部
|
他の一覧 |