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ファイル
言語
英語
著者
内容記述(抄録等)
Coenzyme Q (CoQ) is a component of the electron transport chain that participates in aerobic cellular respiration to produce ATP. In addition, CoQ acts as an electron acceptor in several enzymatic reactions involving oxidation-reduction. Biosynthesis of CoQ has been investigated mainly in Escherichia coli and Saccharomyces cerevisiae, and the findings have been extended to various higher organisms, including plants and humans. Analyses in yeast have contributed greatly to current understanding of human diseases related to CoQ biosynthesis. To date, human genetic disorders related to mutations in eight COQ biosynthetic genes have been reported. In addition, the crystal structures of a number of proteins involved in CoQ synthesis have been solved, including those of IspB, UbiA, UbiD, UbiX, UbiI, Alr8543 (Coq4 homolog), Coq5, ADCK3, and COQ9. Over the last decade, knowledge of CoQ biosynthesis has accumulated and striking advances in related human genetic disorders and the crystal structure of proteins required for CoQ synthesis have been made. This review focuses on the biosynthesis of CoQ in eukaryotes, with some comparisons to the process in prokaryotes.
主題
coenzyme Q
ubiquinone
yeast
human
Arabidopsis
掲載誌名
Bioscience, Biotechnology, and Biochemistry
80
1
開始ページ
23
終了ページ
33
ISSN
0916-8451
ISSN(Online)
1347-6947
発行日
2015-7-17
DOI
資料タイプ
学術雑誌論文
ファイル形式
PDF
関連情報
著者版/出版社版
著者版
業績ID
e29720
部局
生物資源科学部
備考
This is an original manuscript / preprint of an article published by Taylor & Francis in Bioscience, Biotechnology, and Biochemistry on 2015-7-17(online), available online: http://www.tandfonline.com/10.1080/09168451.2015.1065172
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