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ファイル
言語
英語
属性
原著論文
著者
Bai Yunpeng
Nakatani Eiji
岩橋 輝明
田淵 雄基
成相 義樹
狩野 正明
管野 貴浩
Huang Yongqing
Kagimura Tatsuo
Vieth Michael
内容記述(抄録等)
Development of a second primary tumor (SPT)contributes to a poor prognosis, even if the primary oral tumor (OT) was adequately managed. SPT develops as synchronous or metachronous esophageal cancers in 1-20% patients with oral squamous cell carcinoma (OSCC). This study aimed to evaluate the prevalence and associated factors for SPT of the upper digestive tract in 80 Japanese patients with OT (OSCC, oral intraepithelial neoplasia/carcinoma in situ : OIN/CIS, and verrucous carcinoma : VC). SPT were detected in 67 patients, 8 with esophageal carcinoma (EC), 2 with intraepithelial neoplasia (IN), 3 with gastric carcinoma (GC), 7 with epithelial dysplasia (ED), and 47 with other diseases. Malignant tumors (EC, IN, GC), were detected in 13/80 patients (16.3%). Univariate analysis showed that Brinkman index (BI) was a candidate associated factor. In the multivariate analysis, BI as a continuous variable was also a significant associated factor. We strongly suggest that endoscopic screening be performed to identify malignancies of the upper digestive tract in patients with OSCC, OIN/CIS and VC.
主題
oral cancer
esophageal cancer
second primary cancer
associated factor
掲載誌名
Shimane journal of medical science
32
2
開始ページ
81
終了ページ
88
ISSN
03865959
ISSN(Online)
24332410
発行日
2016
NCID
AA00841586
出版者
Shimane University Faculty of Medicine
資料タイプ
紀要論文
ファイル形式
PDF
著者版/出版社版
出版社版
業績ID
e29189
部局
医学部
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