ダウンロード数 : ?
ファイル
言語
英語
著者
奥西 秀樹
Wang, Dan-Qiao
Kakizoe, Eiichi
下浦 惠子
内容記述(抄録等)
We introduce an improved perfusion technique that allows sensitive detection of vasomotion as well as differential estimation of drug action upon luminal or abluminal application. The technique employs a short, isolated segment of medium-sized artery (internal diameter 0.7-4.0mm) that would not generate sufficient resistance by conventional technique. By our method, the constant flow goes through a narrow gap between the intimal surface of the vessel and the outer wall of the blind-end tubing that occupies a large dead-space in the vascular lumen. Due to this narrow clearance, subtle vasomotion can be amplified onto the perfusion pressure, while not much flow-rate is necessary to maintain the baseline perfusion pressure. The method also allows application of drugs either from intimal or adventitial side. This technique should provide powerful means for physiological and pharmacological studies on blood vessels.
掲載誌名
Shimane journal of medical science
18
1
開始ページ
11
終了ページ
20
ISSN
03865959
ISSN(Online)
24332410
発行日
2000-06-01
NCID
AA00841586
出版者別表記
Shimane Medical University
資料タイプ
紀要論文
ファイル形式
PDF
著者版/出版社版
出版社版
部局
医学部
備考
http://ci.nii.ac.jp/vol_issue/nels/AA00841586_jp.html
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