Microbiota maintain colonic homeostasis by activating TLR2/MyD88/PI3K signaling in IL-10-producing regulatory B cells

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言語	英語
著者	三島義之医学部内科学講座内科学第二岡明彦 Liu Bo Center for Gastrointestinal Biology and Disease, Department of Medicine, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill (UNC), Chapel Hill, North Carolina, USA. Herzog Jeremy W. Center for Gastrointestinal Biology and Disease, Department of Medicine, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill (UNC), Chapel Hill, North Carolina, USA. Eun Chang Soo Center for Gastrointestinal Biology and Disease, Department of Medicine, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill (UNC), Chapel Hill, North Carolina, USA.　/　Department of Internal Medicine, Hanyang University Guri Hospital, Guri, South Korea Fan Ting-Jia Department of Internal Medicine, Hanyang University Guri Hospital, Guri, South Korea　/　Department of Microbiology and Immunology, Bulik-Sullivan Emily Department of Nutrition Carroll Ian M. Center for Gastrointestinal Biology and Disease, Department of Medicine, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill (UNC), Chapel Hill, North Carolina, USA　/　Department of Nutrition Hansen Jonathan J. Center for Gastrointestinal Biology and Disease, Department of Medicine, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill (UNC), Chapel Hill, North Carolina, USA　/　Department of Microbiology and Immunology, Chen Liang Lineberger Comprehensive Cancer Center, Department of Genetics Wilson Justin E. Lineberger Comprehensive Cancer Center, Department of Genetics Fisher Nancy C. Department of Microbiology and Immunology Ting Jenny P. Y. Lineberger Comprehensive Cancer Center, Department of Genetics Nochi Tomonori Department of Medicine, Division of Infectious Diseases, UNC, Chapel Hill, North Carolina, USA. 　/　Mucosal Immunology Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan. Wahl Angela Department of Medicine, Division of Infectious Diseases, UNC, Chapel Hill, North Carolina, USA. Garcia J. Victor Department of Medicine, Division of Infectious Diseases, UNC, Chapel Hill, North Carolina, USA. Karp Christopher L. Division of Molecular Immunology, Department of Pediatrics, Cincinnati Children’s Hospital Research Center, Cincinnati, Ohio, USA Sartor R. Balfour Department of Internal Medicine, Hanyang University Guri Hospital, Guri, South Korea　/　Department of Microbiology and Immunology,
掲載誌名	JOURNAL OF CLINICAL INVESTIGATION
巻	129
号	9
開始ページ	3702
終了ページ	3716
ISSN	0021-9738
ISSN（Online）	1558-8238
発行日	2019-09-3
DOI	10.1172/JCI93820
PubMed ID	31211700
出版者	AMER SOC CLINICAL INVESTIGATION INC
資料タイプ	学術雑誌論文
部局	医学部
備考	These studies were supported by NIH grants P01 DK094779, R01 DK53347, P40 OD010995, and P30 DK34987 (to RBS); R01 CA156330 (to JPYT); R01 AI123010 (to AW); and R01 AI111899, AI140799, and MH108179 (to JVG); and by Crohn's and Colitis Foundation Microbiome Initiative and Gnotobiotic Facility grants (both to RBS) and Research Fellowship Award (to YM and AO).; JEW was supported by a postdoctoral fellowship from the American Cancer Society (PF-13-401-01-TBE). The UNC Flow Cytometry Core is supported in part by Cancer Center Core Support Grant P30 CA016086 to the UNC Lineberger Comprehensive Cancer Center. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. The views expressed herein do not necessarily represent the views of the Bill & Melinda Gates Foundation. The authors acknowledge the editorial assistance of Richard Youngblood of the UNC Translational and Clinical Sciences Institute.