SAMR-Web was designed as a user-friendly system for crystal structure determination of proteins by the method of molecular replacement(MR)running over World Wide Web. It was linked to Web sites of PDB and Swiss-Model,and was able to run AMoRe or EPMR which were programs for MR. It is easy and efficient to prepare a search model and input data for running the programs AMoRe or EPMR by using a favorite web browser.