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ファイル
言語
英語
属性
Original article
著者
宮地 葵
秋保 美月
真子 卓也
永野 聖
内容記述(抄録等)
Qualitative changes in the extracellular matrix have been reported in thickened ligamentum flavum (LF) in lumbar spinal canal stenosis (LSCS); however, no detailed quantitative reports are available to date. Degenerated and undegenerated LF were collected from patients who underwent decompression surgery for LSCS and lumbar disc herniation, respectively. Three cylindrical samples of 2.5 mm diameter were cut from one LF specimen, completely solubilized, and quantified glycosaminoglycan (GAG), collagen (COL), and elastin. The amounts of GAG, COL, and elastin in the LSCS group were significantly higher than those in the control group. Although the GAG was originally present only in trace amounts, GAG proportion, standardized by dry weight, was the highest increase rate. Besides component analysis, histologic analysis showed intraligamentous chondrometaplasia in the caudal portion of the degenerated LF. Increased GAG in LF may be a new therapeutic target in LSCS.
主題
lumbar spinal canal stenosis
ligamentum flavum
glycosaminoglycan
collagen, elastin
掲載誌名
Shimane Journal of Medical Science
40
1-2
開始ページ
1
終了ページ
8
ISSN
03865959
ISSN(Online)
24332410
発行日
2023-06
NCID
AA00841586
DOI
出版者
Faculty of Medicine, Shimane University
出版者別表記
島根大学医学部
資料タイプ
紀要論文
ファイル形式
PDF
権利関係
Faculty of Medicine, Shimane University
権利関係(リンク)
著者版/出版社版
出版社版
部局
医学部
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