ダウンロード数 : ?
ファイル
言語
日本語
著者
Martha Clare Morris Rush University Medical Center
粟野 貴子
橋本 道男
植木 彰 自治医科大学付属さいたま医療センター神経内科
内容記述(抄録等)
A growing body of evidence from animal and human studies links dietary fat composition, blood lipids, and cholesterol to the development of dementia.
Cholesterol is central to the process of Alzheimer's disease. The primary genetic risk factor for late onset Alzheimer's disease is the apolipoprotein E (APOE)-e4 allele. Apolipoprotein E is involved in cholesterol transport. The composition of dietary fats affects levels of blood cholesterol and other circulating lipids.
Of the different types of dietary fats, saturated and trans fats increase blood LDL-cholesterol. Blood cholesterol level and a hypercholesterolemic diet have been associated with cognitive decline, Alzheimer's disease and brain neuropathology. Recent studies in animal models and in humans suggest that the deleterious effects of these hypercholesterolemic diets on the brain may be far worse in the presence of dietary copper. The n-3 class of polyunsaturated fat (PUFA) obtained from marine and plant sources has been associated with slower rate of cognitive decline and lower risk of developing Alzheimer's disease. The n-3 PUFA, docosahexaenoic acid (DHA) has been targeted as particularly important for brain function, and is the primary lipid in the most metabolically active areas of the brain. Several randomized clinical trials are currently underway to test the effects of n-3 fatty acid supplementation on cognitive decline and the development of Alzheimer's disease.
主題
アルツハイマー病
食餌脂質組成
n-3脂肪酸摂取量
ドコサヘキサエン酸
掲載誌名
脂質栄養学
17
1
開始ページ
7
終了ページ
18
ISSN
1343-4594
ISSN(Online)
1883-2237
発行日
2008
DOI
出版者
日本脂質栄養学会
出版者ヨミ
ニホン シシツ エイヨウ ガッカイ
出版者別表記
Japan Society for Lipid Nutrition
資料タイプ
学術雑誌論文
ファイル形式
PDF
著者版/出版社版
出版社版
業績ID
e1693
部局
医学部
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