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タイトルヨミ
ヒト センショクタイ オ ホユウスル キメラマウス タイシ ニ オケル ハッセイ イジョウ
日本語以外のタイトル
Developmental anomalies in the foetuses of a chimeric mouse containing a human chromosome
ファイル
言語
日本語
著者
舟木 賢治
内容記述(抄録等)
Chimeric mice containing a human chromosome were produced by introducing a human chromosome into mouse embryonic stem cells via microcell-mediated chromosome transfer.
In present study, the dead foetuses of the chimeric mice containing a human chromosome 2-derived fragment (hChr.2f) or a human chromosome 21 (hChr.21) were studied anatomically in order to examine the effects of introduction of a human chromosome to mouse. Polydactyly were obsered in almost of the chimeric foetuses containing hChr.2f, but were not detected in the chimeric foetuses containing hChr.21. Aplasia of the sternum and delayed ossification or deletion of the cervical vertebrae centrum were universally observed in both the chimericfoetuses. Histological abnormalities in heart and liver were frequently detected in both the chimeric foetuses. Interestingly, the number of germ cells decreased remarkably in all of the chimeric foetuses containing hChr.21.
掲載誌名
島根大学教育学部紀要. 自然科学
35
開始ページ
1
終了ページ
8
ISSN
05869943
発行日
2001-12-01
NCID
AN00107941
出版者
島根大学教育学部
出版者別表記
The Faculty of Education Shimane University
資料タイプ
紀要論文
部局
教育学部
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