ダウンロード数 : ?
ファイル
言語
英語
著者
山口 徹
名和田 清子
田中 賢一郎
髙岡 伸
内容記述(抄録等)
Although a high serum low-density lipoprotein cholesterol (LDL-C) level is an established risk factor for atherosclerosis, it is unclear whether it is associated with osteoporosis. In this study, the associations between the serum LDL-C level and bone mineral density (BMD), bone metabolic markers, and the presence of prevalent vertebral or non-vertebral fractures were examined. A total of 211 healthy postmenopausal women (age range, 46-80 years) who visited a community health center were recruited consecutively. Their radiographic and biochemical characteristics were collected. Prevalent vertebral and non-vertebral fractures were found in 49 (23.2 %) and 36 (17.1 %) subjects, respectively. Simple regression analyses showed that the serum LDL-C level was not significantly correlated with lumbar or femoral BMD or serum levels of total amino-terminal propeptide of type I collagen (PINP) or carboxy-terminal telopeptide of type I collagen (CTX). Logistic regression analyses adjusted for age and BMI showed that the increased serum LDL-C level was selected as an index affecting the presence of prevalent non-vertebral fractures, but not vertebral fractures. This result was still significant after additional adjustments for years since menopause, physical activity, previous cardiovascular events, bone markers, BMD, serum Ca, P, Cr, 25(OH)D, grip strength, tandem gait test, and use of drugs for hyperlipidemia [odds ratio 1.76 (1.13-2.73), p = 0.012]. These findings suggest that a high serum LDL-C level may be a risk factor for prevalent non-vertebral fragility fractures independent of bone turnover, bone mass, vitamin D insufficiency, or frail status in postmenopausal women, and that it may be detrimental to bone, as well as blood vessels.
主題
Low-density lipoprotein cholesterol
Non-vertebral fracture
Osteoporosis
Postmenopausal women
Bone mineral density
Dislipidemia
Hypercholesterolemia
Vitamin D
掲載誌名
Endocrine
48
1
開始ページ
279
終了ページ
286
ISSN
15590100
発行日
2015-02
DOI
DOI公開日
2017-03-23
PubMed ID
NCID
AA12629840
出版者
Springer
資料タイプ
学術雑誌論文
ファイル形式
PDF
権利関係
© Springer Science+Business Media New York 2014
著者版/出版社版
著者版
業績ID
e26990
e27138
部局
医学部 医学科
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