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ファイル
言語
英語
属性
Original article
著者
平山 奈々恵
安部 由美子
内容記述(抄録等)
Drug delivery systems, drugs are administered into the amniotic fluid, may contribute to fetal therapy. The present study explored changes in the volume of amniotic fluid from E11.5 through E17.5, and kinetics of calcein-containing liposomal particles incubated in the amniotic fluid collected at E12.5, E14.5, and E16.5 in Jcl/ICR mice. The volume of amniotic fluid increased until E15.5, followed by a sharp decrease at E17.5. The calcein release rate remained within 4% until day 14 in serum and each amniotic fluid. No significant differences were noted in the release rate between the serum and amniotic fluid at various time points. Therefore, the calcein release rate of liposomal nanoparticles in the amniotic fluid remained low and did not differ from that in the serum for as long as 14 days at different time points during gestation. These observations suggest that liposomal nanoparticles remain stable for prolonged periods in the amniotic fluid.
主題
liposomal particle
amniotic fluid
mouse
掲載誌名
Shimane Journal of Medical Science
40
3-4
開始ページ
55
終了ページ
60
ISSN
03865959
ISSN(Online)
24332410
発行日
2023-12
NCID
AA00841586
DOI
出版者
Faculty of Medicine, Shimane University
出版者別表記
島根大学医学部
資料タイプ
紀要論文
ファイル形式
PDF
権利関係
Faculty of Medicine, Shimane University
権利関係(リンク)
著者版/出版社版
出版社版
部局
医学部
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