ダウンロード数 : ?
File
language
eng
Author
Kessoku, Takaomi
Imajo, Kento
Honda, Yasushi
Kato, Takayuki
Ogawa, Yuji
Tomeno, Wataru
Kato, Shingo
Mawatari, Hironori
Fujita, Koji
Yoneda, Masato
Nagashima, Yoji
Saito, Satoru
Nakajima, Atsushi
Description
The natural polyphenol compound resveratrol (RSV) is considered to have a broad spectrum of beneficial biological activities upon human health. However, the exact effect of RSV on steatosis (a phenotype of non-alcoholic fatty liver [NAFL]) or fibrosis and inflammation (major phenotypes of non-alcoholic steatohepatitis [NASH]) is not known. Our data showed that administration of RSV (2 or 20 mg/kg/day) did not suppress steatosis in a high-fat diet-induced model of NAFL in mice. In contrast, identical concentrations of RSV dramatically inhibited inflammation and fibrosis in a low-dose lipopolysaccharide-induced model of NASH. These data suggested that RSV administration-mediated improvement of inflammation and fibrosis was due to the inhibition of LPS reactivity controlled by CD14 expression in Kupffer cells. These findings suggest that RSV could be a candidate agent for the treatment of NASH.
Subject
NASH
Resveratrol
Journal Title
Scientific Reports
Volume
6
Start Page
22251-1
End Page
22251-11
ISSN
20452322
Published Date
2016-02-25
DOI
PubMed ID
Publisher
Springer Nature
NII Type
Journal Article
Format
PDF
Rights
© The Author(s) 2016. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Text Version
出版社版
Gyoseki ID
e28541
OAI-PMH Set
School of Medicine, Faculty of Medicine
このエントリーをはてなブックマークに追加