ダウンロード数 : ?
ファイル
言語
英語
著者
Kessoku, Takaomi
Imajo, Kento
Honda, Yasushi
Kato, Takayuki
Ogawa, Yuji
Tomeno, Wataru
Kato, Shingo
Mawatari, Hironori
Fujita, Koji
Yoneda, Masato
Nagashima, Yoji
Saito, Satoru
Nakajima, Atsushi
内容記述(抄録等)
The natural polyphenol compound resveratrol (RSV) is considered to have a broad spectrum of beneficial biological activities upon human health. However, the exact effect of RSV on steatosis (a phenotype of non-alcoholic fatty liver [NAFL]) or fibrosis and inflammation (major phenotypes of non-alcoholic steatohepatitis [NASH]) is not known. Our data showed that administration of RSV (2 or 20 mg/kg/day) did not suppress steatosis in a high-fat diet-induced model of NAFL in mice. In contrast, identical concentrations of RSV dramatically inhibited inflammation and fibrosis in a low-dose lipopolysaccharide-induced model of NASH. These data suggested that RSV administration-mediated improvement of inflammation and fibrosis was due to the inhibition of LPS reactivity controlled by CD14 expression in Kupffer cells. These findings suggest that RSV could be a candidate agent for the treatment of NASH.
主題
NASH
Resveratrol
掲載誌名
Scientific Reports
6
開始ページ
22251-1
終了ページ
22251-11
ISSN
20452322
発行日
2016-02-25
DOI
PubMed ID
出版者
Springer Nature
資料タイプ
学術雑誌論文
ファイル形式
PDF
権利関係
© The Author(s) 2016. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
著者版/出版社版
出版社版
業績ID
e28541
部局
医学部
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