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language
eng
Author
Yamasaki, Masayuki Department of Environmental and Preventive Medicine, Faculty of Medicine, Shimane University
Paulin Beya wa Bitadi Mutombo Faculty of Medicine, University of Kinshasa
Iwamoto, Mamiko Department of Environmental and Preventive Medicine, Faculty of Medicine, Shimane University
Nogi, Akiko Faculty of Nursing and Human Nutrition, Yamaguchi Prefectural University
Hashimoto, Michio Department of Environmental Physiology, Faculty of Medicine, Shimane University
Nabika, Toru Department of Functional Pathology, Faculty of Medicine, Shimane University
Shiwaku, Kuninori Shimane University
Description
BACKGROUND/OBJECTIVE: Apolipoprotein A5 gene promoter region T-1131C polymorphism (APOA5 T-1131C) is known to be associated with elevated plasma TG levels, although little is known of the influence of the interaction between APOA5 T-1131C and lifestyle modification on TG levels. To investigate this matter, we studied APOA5 T-1131C and plasma TG levels of subjects participating in a three-month lifestyle modification program.
SUBJECTS/METHODS: A three-month lifestyle modification program was conducted with 297 participants (Age: 57 ± 8 years) in Izumo City, Japan, from 2001-2007. Changes in energy balance (the difference between energy intake and energy expenditure) and BMI were used to evaluate the participants' responses to the lifestyle modification.
RESULTS: Even after adjusting for confounding factors, plasma TG levels were significantly different at baseline among three genotype subgroups: TT, 126 ± 68 mg/dl; TC, 134 ± 74 mg/dl; and CC, 172 ± 101 mg/dl. Lifestyle modification resulted in significant reductions in plasma TG levels in the TT, TC, and CC genotype subgroups: -21.9 ± 61.0 mg/dl, -20.9 ± 51.0 mg/dl, and -42.6 ± 78.5 mg/dl, respectively, with no significant differences between them. In a stepwise regression analysis, age, APOA5 T-1131C, body mass index (BMI), homeostasis model assessment-insulin resistance (HOMA-IR), and the 18:1/18:0 ratio showed independent association with plasma TG levels at baseline. In a general linear model analysis, APOA5 T-1131C C-allele carriers showed significantly greater TG reduction with decreased energy balance than wild type carriers after adjustment for age, gender, and baseline plasma TG levels.
CONCLUSIONS: The genetic effects of APOA5 T-1131C independently affected plasma TG levels. However, lifestyle modification was effective in significantly reducing plasma TG levels despite the APOA5 T-1131C genotype background.
Subject
APOA5 T-1131C
Plasma TG
energy balance
lifestyle modification
Journal Title
Nutrition research and practice
Volume
9
Issue
4
Start Page
379
End Page
384
ISSN
19761457
Published Date
2015-08
DOI
PubMed ID
NCID
AA12393085
Publisher
Korean Nutrition Society : Korean Society of Community Nutrition
NII Type
Journal Article
Format
PDF
Rights
©2015 The Korean Nutrition Society and the Korean Society of Community Nutrition
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
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OAI-PMH Set
School of Medicine, Faculty of Medicine
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