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ファイル
言語
英語
著者
山崎 雅之 島根大学医学部環境保健医学講座
Paulin Beya wa Bitadi Mutombo キンシャサ大学
岩本 麻実子 島根大学医学部環境保健医学講座
Nogi, Akiko 山口県立大学
橋本 道男 島根大学医学部環境保健医学講座
並河 徹 島根大学医学部病理学講座
塩飽 邦憲 島根大学
内容記述(抄録等)
BACKGROUND/OBJECTIVE: Apolipoprotein A5 gene promoter region T-1131C polymorphism (APOA5 T-1131C) is known to be associated with elevated plasma TG levels, although little is known of the influence of the interaction between APOA5 T-1131C and lifestyle modification on TG levels. To investigate this matter, we studied APOA5 T-1131C and plasma TG levels of subjects participating in a three-month lifestyle modification program.
SUBJECTS/METHODS: A three-month lifestyle modification program was conducted with 297 participants (Age: 57 ± 8 years) in Izumo City, Japan, from 2001-2007. Changes in energy balance (the difference between energy intake and energy expenditure) and BMI were used to evaluate the participants' responses to the lifestyle modification.
RESULTS: Even after adjusting for confounding factors, plasma TG levels were significantly different at baseline among three genotype subgroups: TT, 126 ± 68 mg/dl; TC, 134 ± 74 mg/dl; and CC, 172 ± 101 mg/dl. Lifestyle modification resulted in significant reductions in plasma TG levels in the TT, TC, and CC genotype subgroups: -21.9 ± 61.0 mg/dl, -20.9 ± 51.0 mg/dl, and -42.6 ± 78.5 mg/dl, respectively, with no significant differences between them. In a stepwise regression analysis, age, APOA5 T-1131C, body mass index (BMI), homeostasis model assessment-insulin resistance (HOMA-IR), and the 18:1/18:0 ratio showed independent association with plasma TG levels at baseline. In a general linear model analysis, APOA5 T-1131C C-allele carriers showed significantly greater TG reduction with decreased energy balance than wild type carriers after adjustment for age, gender, and baseline plasma TG levels.
CONCLUSIONS: The genetic effects of APOA5 T-1131C independently affected plasma TG levels. However, lifestyle modification was effective in significantly reducing plasma TG levels despite the APOA5 T-1131C genotype background.
主題
APOA5 T-1131C
Plasma TG
energy balance
lifestyle modification
掲載誌名
Nutrition research and practice
9
4
開始ページ
379
終了ページ
384
ISSN
19761457
発行日
2015-08
DOI
PubMed ID
NCID
AA12393085
出版者
Korean Nutrition Society : Korean Society of Community Nutrition
資料タイプ
学術雑誌論文
ファイル形式
PDF
権利関係
©2015 The Korean Nutrition Society and the Korean Society of Community Nutrition
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
著者版/出版社版
出版社版
部局
医学部 医学科
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