ダウンロード数 : ?
ファイル
言語
英語
著者
Kawai, Minako Department of Neural and Muscular Physiology, Shimane University School of Medicine, Izumo, Shimane 693-8501, Japan
Hirota, Akihiko Department of Neural and Muscular Physiology, Shimane University School of Medicine, Izumo, Shimane 693-8501, Japan
内容記述(抄録等)
Peripheral nerve injury induces functional reorganization of the central nervous system. The mechanisms underlying this reorganization have been widely studied. Our previous study involving multiple-site optical recording reported that a neural excitatory wave induced by somatic stimulation begins in a small area and propagates in the cortex. In the present study, to examine the possible role of this propagation wave in cortical reorganization, we analyzed the early changes in the spatio-temporal pattern of the sensory-evoked wave immediately, and 30 min, after nerve injury. The response to hypothenar stimulation, innervated by the ulnar nerve and adjoining the median nerve area, persisted after injury to either the ulnar or median nerve. Initially, we assessed changes in the response pattern at the focus. The latency increased after ulnar nerve injury, whereas no change was observed after median nerve injury. Similarly, no change was noted in the duration of the response signal with either nerve injury. Second, changes in the propagation wave pattern were analyzed. Ulnar nerve injury decreased the propagation velocity in the medial direction but the median nerve injury induced no changes. These results indicated that the propagation wave pattern is readily altered, even immediately after nerve injury, and suggest that this immediate change in the spatio-temporal pattern is one of the factors contributing to the cortical reorganization.
主題
optical recording
sensory cortex
propagation wave
peripheral nerve injury
reorganization
掲載誌名
Neuroscience
448
10
開始ページ
85
終了ページ
93
ISSN
0306-4522
発行日
2020-9-14
DOI
出版者
IBRO. Published
資料タイプ
学術雑誌論文
ファイル形式
PDF
著者版/出版社版
著者版
業績ID
40363
部局
医学部