Genome-Wide Association Meta-analysis Identifies Novel Variants Associated With Fasting Plasma Glucose in East Asians

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言語	英語
著者	Hwang Joo-Yeon Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea Sim Xueling Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 　/　Centre for Molecular Epidemiology, National University of Singapore, Singapore, Singapore Wu Ying Department of Genetics, University of North Carolina, Chapel Hill, NC Liang Jun Department of Nutrition, Harvard School of Public Health, Boston, MA Tabara Yasuharu Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan Hu Cheng Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China Hara Kazuo Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan　/　Department of Integrated Molecular Science on Metabolic Diseases, 22nd Century Medical and Research Center, The University of Tokyo, Tokyo, Japan Tam Claudia H. T. Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong Cai Qiuyin Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center; and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN Zhao Qi Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA Jee Sunha Institute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Korea Takeuchi Fumihiko Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan Go Min Jin Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea Ong Rick Twee Hee Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore Ohkubo Takayoshi Department of Planning for Drug Development and Clinical Evaluation, Tohoku University Graduate School of Pharmaceutical Sciences, Sendai, Japan　/　Department of Health Science, Shiga University of Medical Science, Shiga, Japan Kim Young Jin Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea Zhang Rong Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China Yamauchi Toshimasa Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan So Wing Yee Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong Long Jirong Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center; and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN Gu Dongfeng State Key Laboratory of Cardiovascular Disease, Department of Epidemiology, National Center for Cardiovascular Diseases, Beijing, China / Population Genetics, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences, Beijing, China / Peking Union Medical College, Beijing, China Lee Nanette R. Office of Population Studies Foundation, University of San Carlos, Cebu City, Philippines Kim Soriul Institute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Korea Katsuya Tomohiro Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Suita, Japan Oh Ji Hee Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea Liu Jianjun Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore Umemura Satoshi Department of Medical Science and Cardiorenal Medicine, Yokohama City University School of Medicine, Yokohama, Japan Kim Yeon-Jung Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea Jiang Feng Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China Maeda Shiro Laboratory for Endocrinology, Metabolism and Kidney Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan Chan Juliana C. N. Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong Lu Wei Shanghai Municipal Center for Disease Control & Prevention, Shanghai, China Hixson James E. Human Genetics Center, The University of Texas School of Public Health, Houston, TX Adair Linda S. Department of Nutrition, University of North Carolina, Chapel Hill, NC Jung Keum Ji Institute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Korea 並河徹 Bae Jae-Bum Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea Lee Mi Hee Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea Seielstad Mark Institute for Human Genetics, University of California, San Francisco, San Francisco, CA Young Terri L. Center for Human Genetics, Duke University Medical Center, Durham, NC Teo Yik Ying Centre for Molecular Epidemiology, National University of Singapore, Singapore, Singapore 　/　Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore 　/　Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore 　/　Department of Statistics and Applied Probability, National University of Singapore, Singapore, Singapore Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore, Singapore Kita Yoshikuni Department of Health Science, Shiga University of Medical Science, Shiga, Japan Takashima Naoyuki Department of Health Science, Shiga University of Medical Science, Shiga, Japan Osawa Haruhiko Department of Molecular and Genetic Medicine, Ehime University Graduate School of Medicine, Toon, Japan Lee So-Hyun Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea Shin Min-Ho Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, South Korea Shin Dong Hoon Department of Occupational and Environmental Medicine, Keimyung University Dongsan Medical Center, Daegu, South Korea Choi Bo Youl Department of Preventive Medicine, College of Medicine, Hanyang University, Seoul, Korea Shi Jiajun Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center; and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN Gao Yu-Tang Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Xiang Yong-Bing Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Zheng Wei Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center; and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN Kato Norihiro Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan Yoon Miwuk Institute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Korea He Jiang Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA Shu Xiao Ou Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center; and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN Ma Ronald C. W. Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong Kadowaki Takashi Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan Jia Weiping Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China Miki Tetsuro Department of Geriatric Medicine, Ehime University Graduate School of Medicine, Toon, Japan Qi Lu Department of Nutrition, Harvard School of Public Health, Boston, MA Tai E. Shyong Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan 　/　Department of Medicine, National University of Singapore, Singapore, Singapore 　/　Duke-National University of Singapore Graduate Medical School, Singapore, Singapore Mohlke Karen L. Department of Genetics, University of North Carolina, Chapel Hill, NC Han Bok-Ghee Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea Cho Yoon Shin Department of Biomedical Science, Hallym University, Chuncheon, Korea Kim Bong-Jo Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea
掲載誌名	DIABETES
巻	64
号	1
開始ページ	291
終了ページ	298
ISSN	0012-1797
ISSN（Online）	1939-327X
発行日	2015-01
DOI	10.2337/db14-0563
PubMed ID	25187374
出版者	AMER DIABETES ASSOC
資料タイプ	学術雑誌論文
部局	医学部
備考	This work was supported by grants from Korea Centers for Disease Control and Prevention (4845-301, 4851-302, and 4851-307) and an intramural grant from the Korea National Institute of Health (2012-N73002-00), the Republic of Korea. Y.S.C. acknowledges support from the National Research Foundation of Korea grant funded by the Korean government (Ministry of Education, Science and Technology) (2012R1A2A1A03006155). CLHNS was supported by U.S. National Institutes of Health (NIH) grants DK078150, TW05596, HL085144, and TW008288 and pilot funds from RR20649, ES10126, and DK56350. The authors thank the Office of Population Studies Foundation research and data collection teams and the study participants who generously provided their time for this study. The authors thank Markku Laakso (University of Kuopio, Finland), Michael Boehnke (University of Michigan), Francis Collins (NIH, Bethesda, MD), and the METSIM study investigators for providing access to unpublished data. METSIM data were generated and analyzed with support from the Academy of Finland (contract 124243), the Finnish Heart Foundation, the Finnish Diabetes Foundation, Tekes (contract 1510/31/06), the Commission of the European Community (HEALTH-F2-2007-201681), and NIH grants DK093757, DK072193, DK062370, and 1Z01 HG000024. SBCS was supported by R01CA064277; SMHS by R01CA082729; and GWA studies by R37CA070867, R01CA082729, R01CA124558, R01CA148667, R01CA122364, R01CA122756, and R01CA137013 (all NIH grants), as well as Ingram Professorship and Research Reward funds from the Vanderbilt University School of Medicine. The authors want to thank Regina Courtney (the Vanderbilt University School of Medicine) for DNA preparation and Jing He (the Vanderbilt University School of Medicine) for data processing and analyses. S.O.U. acknowledges a grant from the National 973 Program (2011CB504001), National Natural Science Foundation of China (81170735), and Excellent Young Medical Expert of Shanghai (XYQ2011041). The authors thank all the medical staff of the Shanghai Clinical Center for Diabetes, all the participants and the staff of the BioBank Japan project, and Minoru Iwata, Kazuyuki Tobe (First Department of Internal Medicine, University of Toyama), Kazuki Yasuda, Masato Kasuga (Diabetes Research Center, Research Institute, National Center for Global Health and Medicine), and Hiroshi Hirose (Health Center, Keio University School of Medicine) for the preparation of DNA and clinical information. They also thank the technical staff of the Laboratory for Endocrinology, Metabolism and Kidney diseases at the RIKEN Center for Integrative Medical Sciences for performing SNP genotyping. They thank Hayato Fujita (Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo) for statistical analysis. S.M. acknowledges a grant from the Leading Project of Ministry of Education, Culture, Sports, Science and Technology, Japan. W.J. acknowledges a grant from the National Natural Science Foundation of China (81322010 and 81170735), National 863 Program (2012AA02A509), Shanghai Rising Star Program (12QH1401700), Shanghai Talent Development Grant (2012041), Excellent Young Medical Expert of Shanghai (XYQ2011041), and National Young Top Talent Support Program.; The authors would like to acknowledge support from the Hong Kong Foundation for Research and Development in Diabetes, established under the auspices of the Chinese University of Hong Kong, the Hong Kong government Research Grant Committee Central Allocation Scheme (CUHK 1/04C) and Theme-Based Research Scheme (T12-402/13-N), the Innovation and Technology Fund (ITS/088/08 and ITS/487/09FP), a Chinese University Direct Grant, and NIH grant NIH-RFA DK-085545-01 (from the National Institute of Diabetes and Digestive and Kidney Diseases). GenSalt is supported by research grants (U01HL072507, R01HL087263, and R01HL090682) from the NIH National Heart, Lung, and Blood Institute.