ダウンロード数 : ?
タイトルヨミ
ダッカイコツ キシツ ユウドウセイ ナンコツナイ カコツ ニ オヨボス エストロジェン ノ エイキョウ
日本語以外のタイトル
Effect of Estrogen on Decalcified Bone Matrix-induced Endochondral Bone Formation in Rats
ファイル
言語
英語
著者
松井 徹
内容記述(抄録等)
The influence of deficiency and administration of estrogen on the discrete phases of decalcified bone matrix induced endochondral bone formation was investigated. In ovariectomized (Ovx), sham operated (Sham) and sham operated and estrogen administrated (Sham+E) rats, chondrogenesis, cartilage degeneration and bone formation, and bone remodeling were occurred 7, 14 and 21 days after implantation of bone matrix, respectively. Calcium contents and alkaline phosphatase activity were less in Ovx than in the other groups during the experiment. Alkaline phosphatase activity was not different between Sham and Sham+E rats but calcium content was more on day 14 and less on day 21 in Sham+E than in Sham group. Calcium dependent ATPase activity was increased in Sham on day 21 but the activity was decreased in Sham+E animals. It is suggested that cartilage and bone differentiation were occurred notwithstanding estrogen deficiency and administration. Though estrogen deficiency suppresses calcification of bone and cartilage, exogenous estrogen induces rapid calcification of cartilage and suppresses calcium deposition of bone which may be related to calcium dependent ATPase activity.
掲載誌名
島根大学農学部研究報告
21
開始ページ
28
終了ページ
33
ISSN
0370940X
発行日
1987-12-21
NCID
AN00108015
出版者
島根大学農学部
出版者別表記
Shimane University, Faculty of Agriculture
資料タイプ
紀要論文
部局
生物資源科学部
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