ダウンロード数 : ?
ファイル
言語
英語
属性
Original article
著者
JAYA, Muhammad Alim
林田 麻衣子
土江 景子
JERIN, Sultana Jannatul Ferdoush
MAMUNUR, Rahman
三浦 章子
宮岡 剛
TANRA, Andi Jayalangkara
堀口 淳
内容記述(抄録等)
Depression is one of the most common mental disorders. Glial cells have been reported to play a role in the pathogenesis of depression. Meanwhile, Ninjin’yoeito (NYT), a Kampo medicine, is a multi-component drug that was reported to improve depressive symptoms in patient and animal models. In addition, some of its components have an effect on glial cells. However, the mechanism remains unclear. The study’s aim was to investigate the effect of NYT in recovering depressive-like behavior and glial pathological changes in the hippocampus induced by lipopolysaccharide. Here, we showed that NYT improved the forced swim test performances of the rat. Furthermore, NYT also inhibited microglial activation in the hippocampus, but the results were different in astrocytes. These results suggest that NYT alleviates depressive-like behavior, and the effect may be associated with the attenuation of glial cell activation.
主題
ninjin’yoeito
kampo medicine
depressive behavior
glial cells
lipopolysaccharide
forced swim tests
掲載誌名
Shimane Journal of Medical Science
39
1
開始ページ
1
終了ページ
13
ISSN
03865959
ISSN(Online)
24332410
発行日
2022-03
NCID
AA00841586
DOI
出版者
Faculty of Medicine, Shimane University
出版者別表記
島根大学医学部
資料タイプ
紀要論文
ファイル形式
PDF
権利関係
Faculty of Medicine, Shimane University
権利関係(リンク)
著者版/出版社版
出版社版
部局
医学部
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