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The Effect of Intravenous Lidocaine on the Response of Medullary Inspiratory Neurons to CO_2 in Cats
ファイル
言語
英語
著者
笠羽 敏治
小坂 義弘
内容記述(抄録等)
The effect of intravenous lidocaine on the response of medullary inspiratory neurons to CO_2 was studied in 11 urethane-anesthetized ventilated cats. Lidocaine was administrated at a subconvulsive dose through a venous cannula by means of a constant-rate infusion pump (0.3-0.5mg・kg^<-1>・min^<-1>). We compared the number of spikes before and after CO_2 administration in a lidocaine-free state. Then, we likewise compared the number of spikes before and after CO_2 administration in a lidocaine administered-state. The rate of increase of spikes per mmHg of PaCO_2 was 1.49±0.72 spike・mmHg^<-1> in the control lidocaine-free group, and 0.96±0.51 spike・mmHg^<-1> in the lidocaine-administered group. The response to CO_2 was significantly suppressed in the lidocaine group (p<0.05). These results suggest that systemic lidocaine suppresses respiratory center in the urethane-anesthetized cats.
主題
carbon dioxide
cats
lidocaine
掲載誌名
Shimane journal of medical science
12
開始ページ
23
終了ページ
30
ISSN
03865959
ISSN(Online)
24332410
発行日
1990
NCID
AA00841586
出版者別表記
Shimane Medical University
資料タイプ
紀要論文
ファイル形式
PDF
著者版/出版社版
出版社版
部局
医学部
他の一覧