ファイル | |
言語 |
英語
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属性 |
Research Article
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著者 |
Hie LimKim
Center for the Promotion of Integrated Sciences, The Graduate University for Advanced Studies (SOKENDAI), Hayama, Kanagawa 240-0193, Japan
Takeshi Igawa
Institute for Amphibian Biology, Graduate School of Science, Hiroshima University, Higashihiroshima, Hiroshima 739-8526, Japan
Tasuku Nishioka
Center for the Promotion of Integrated Sciences, The Graduate University for Advanced Studies (SOKENDAI), Hayama, Kanagawa 240-0193, Japan
Satoko Kaneko
Laboratory of Plant Genetics, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan
Yukako Katsura
Department of Evolutionary Studies of Biosystems, The Graduate University for Advanced Studies (SOKENDAI), Hayama, Kanagawa 240-0193, Japan
Naoyuki Takahata
The Graduate University for Advanced Studies (SOKENDAI), Hayama, Kanagawa 240-0193, Japan
Yoko Satta
Department of Evolutionary Studies of Biosystems, The Graduate University for Advanced Studies (SOKENDAI), Hayama, Kanagawa 240-0193, Japan
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内容記述(抄録等) | We report the results of an extensive investigation of genomic structures in the human genome, with a particular focus on relatively large repeats (>50 kb) in adjacent chromosomal regions. We named such structures “Flowers” because the pattern observed on dot plots resembles a flower. We detected a total of 291 Flowers in the human genome. They were predominantly located in euchromatic regions. Flowers are gene-rich compared to the average gene density of the genome. Genes involved in systems receiving environmental information, such as immunity and detoxification, were overrepresented in Flowers. Within a Flower, the mean number of duplication units was approximately four. The maximum and minimum identities between homologs in a Flower showed different distributions; the maximum identity was often concentrated to 100% identity, while the minimum identity was evenly distributed in the range of 78% to 100%. Using a gene conversion detection test, we found frequent and/or recent gene conversion events within the tested Flowers. Interestingly, many of those converted regions contained protein-coding genes. Computer simulation studies suggest that one role of such frequent gene conversions is the elongation of the life span of gene families in a Flower by the resurrection of pseudogenes.
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掲載誌名 |
International Journal of Evolutionary Biology
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巻 | 2012
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開始ページ | 1
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終了ページ | 11
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ISSN | 2356-6140
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ISSN(Online) | 1537-744X
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発行日 | 2012-01-19
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DOI | |
出版者 | Hindawi Publishing Corporation
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資料タイプ |
学術雑誌論文
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ファイル形式 |
PDF
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権利関係 | Copyright © 2012 Hie Lim Kim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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著者版/出版社版 |
出版社版
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業績ID | e29713
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部局 |
他機関
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備考 | Article ID 917678
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