Fibril formation and therapeutic targeting of amyloid-like structures in a yeast model of adenine accumulation

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言語	英語
著者	Laor Dana Department of Molecular Microbiology and Biotechnology, George S. Wise Faculty of Life Sciences, Tel Aviv University, 69978, Tel Aviv, Israel Sade Dorin Department of Molecular Microbiology and Biotechnology, George S. Wise Faculty of Life Sciences, Tel Aviv University, 69978, Tel Aviv, Israel Shaham-Niv Shira Department of Molecular Microbiology and Biotechnology, George S. Wise Faculty of Life Sciences, Tel Aviv University, 69978, Tel Aviv, Israel Zaguri Dor Department of Molecular Microbiology and Biotechnology, George S. Wise Faculty of Life Sciences, Tel Aviv University, 69978, Tel Aviv, Israel Gartner Myra Department of Molecular Microbiology and Biotechnology, George S. Wise Faculty of Life Sciences, Tel Aviv University, 69978, Tel Aviv, Israel Basavalingappa Vasantha Department of Molecular Microbiology and Biotechnology, George S. Wise Faculty of Life Sciences, Tel Aviv University, 69978, Tel Aviv, Israel Raveh Avi BLAVATNIK CENTER for Drug Discovery, Tel Aviv University, 6997801, Tel Aviv, Israel Pichinuk Edward BLAVATNIK CENTER for Drug Discovery, Tel Aviv University, 6997801, Tel Aviv, Israel Engei Hamutal BLAVATNIK CENTER for Drug Discovery, Tel Aviv University, 6997801, Tel Aviv, Israel Lwasaki Keita Faculty of Life and Environmental Science, Shimane University, Matsue, 690-8504, Japan 山本達之 Noothalapati Hemanth Raman Center for Medical and Biological Applications, Shimane University, Matsue, 690-8504, Japan Gazit Ehud Department of Molecular Microbiology and Biotechnology, George S. Wise Faculty of Life Sciences, Tel Aviv University, 69978, Tel Aviv, Israel BLAVATNIK CENTER for Drug Discovery, Tel Aviv University, 6997801, Tel Aviv, Israel Department of Materials Science and Engineering, Iby and Aladar Fleischman Faculty of Engineering, Tel Aviv University, 69978, Tel Aviv, Israel
掲載誌名	NATURE COMMUNICATIONS
巻	10
ISSN	2041-1723
発行日	2019-01-8
DOI	10.1038/s41467-018-07966-5
PubMed ID	30622276
出版者	NATURE PUBLISHING GROUP
資料タイプ	学術雑誌論文
部局	生物資源科学部
備考	We thank A. Brandis for GC-MS analysis, E. Haimov and B. Redko for LC-MS analysis, A. Lichtenstein for confocal microscopy analysis, O. Sagi-Assif for the fluorescence-activated cell sorting analysis, B. Lifshitz and L. Gershon for assistance with plasmids cloning, K. Simpson-Lavy for assistance with the Hsp104 experiments, T. Guterman for assistance in Fig. 1d, S. Rencus-Lazar for proofreading the article. We thank A. Parket and members of the Gazit, Adler-Abramovich, and Kupiec laboratories for helpful discussions. This work was supported by the Israel Science Foundation (Grant no. 802/15; E.G.) and by the Adelis Forever Foundation (E.G.). This research was a collaboration with the BCDD, funded by Len Blavatnik and the Blavatnik Family Foundation. This work is dedicated to the memory of Prof. Susan L. Lindquist (1949-2016), a pioneer and visionary in the establishment of yeast models of neurodegenerative amyloid disorders and their therapeutic treatment.