ダウンロード数 : ?
ファイル
言語
英語
著者
浦上慎司 ウラカミ
白川 浩希
石部 知行
嘉手納 一志
碓井 亞
内容記述(抄録等)
A total of 16 patients with muscle invasive bladder cancer, clinical stage T2N0M0 (6), T3aN0M0 (7) or T3bN0M0 (3), underwent 1 to 4 cycles of neoadjuvant cisplatin-based chemotherapy followed by either partial cystectomy or transurethral resection. The overall response rate to the chemotherapy was 56% (95% confidence limits 32 to 79%). For the stages T2 and T3a cancer patients the overall response rate was 69%, while all 3 patients with T3b cancer showed incomplete response. Ten (63%) of 16 patients relapsed. Recurrence of superficial bladder cancer was observed in 5 patients with T2G2-3 or T3aG2 tumors, whereas invasive bladder cancer or metastases developed in 5 patients with T3a-3bG3 tumors. Eleven (69%) patients are alive with a functional bladder at a median followup of 48 months+. While bladder preservation may be permitted in selected patients with T2-3a disease, it is inconclusive whether neoadjuvant chemotherapy improves the survival of patients with invasive bladder cancer.
主題
Neoadjuvant chemotherapy
Bladder cancer
Bladder preservation
掲載誌名
Shimane journal of medical science
14
開始ページ
15
終了ページ
17
ISSN
03865959
ISSN(Online)
24332410
発行日
1996
NCID
AA00841586
出版者別表記
Shimane Medical University
資料タイプ
紀要論文
ファイル形式
PDF
著者版/出版社版
出版社版
業績ID
e28121
e28133
部局
医学部
他の一覧