Pertuzumab retreatment for HER2-positive advanced breast cancer: A randomized, open-label phase III study (PRECIOUS)

Yutaka Yamamoto 1, Hiroji Iwata 2, Naruto Taira 3, Norikazu Masuda 4, Masato Takahashi 5, Tetsuhiro Yoshinami 6 7, Takayuki Ueno 8, Tatsuya Toyama 9, Takashi Yamanaka 10, Toshimi Takano 11 12, Masahiro Kashiwaba 13 14, Koichiro Tsugawa 15, Yoshie Hasegawa 16, Kenji Tamura 17 18, Hiroshi Tada 19, Fumikata Hara 12 20, Tomomi Fujisawa 21, Naoki Niikura 22, Shigehira Saji 23, Satoshi Morita 24, Masakazu Toi 25, Shinji Ohno 26 1Department of Breast and Endocrine Surgery, Kumamoto University Hospital, Kumamoto, Japan. 2Department of Breast Oncology, Aichi Cancer Center Hospital, Nagoya, Japan. 3Department of Breast and Endocrine Surgery, Okayama University Hospital, Okayama, Japan. 4Department of Breast and Endocrine Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan. 5Department of Breast Surgery, National Hospital Organization Hokkaido Cancer Center, Sapporo, Japan. 6Department of Medical Oncology, Osaka International Cancer Institute, Osaka, Japan. 7Department of Breast and Endocrine Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan. 8Breast Surgical Oncology, Breast Oncology Center, The Cancer Institute Hospital of the JFCR, Tokyo, Japan. 9Department of Breast Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan. 10Department of Breast and Endocrine Surgery, Kanagawa Cancer Center, Yokohama, Japan. 11Department of Medical Oncology, Toranomon Hospital, Tokyo, Japan. 12Breast Medical Oncology, Breast Oncology Center, The Cancer Institute Hospital of JFCR, Tokyo, Japan. 13Department of Breast Surgery, Social Medical Corporation Hakuaikai, Sagara Hospital, Kagoshima, Japan. 14Department of Breast Surgery, Adachi Breast Clinic, Kyoto, Japan. 15Department of Surgery, St. Marianna University School of Medicine, Kawasaki, Japan. 16Department of Breast Surgery, Hirosaki Municipal Hospital, Aomori, Japan. 17Department of Breast and Medical Oncology, National Cancer Center Hospital, Tokyo, Japan. 18Department of Medical Oncology, Shimane University Hospital, Izumo, Japan. 19Department of Breast and Endocrine Surgical Oncology, Graduate School of Medicine, Tohoku University, Sendai, Japan. 20Department of Breast Oncology, National Hospital Organization Shikoku Cancer Center, Matsuyama, Japan. 21Department of Breast Oncology, Gunma Prefectural Cancer Center, Ota, Japan. 22Department of Breast Oncology, Tokai University Hospital, Isehara, Japan. 23Department of Medical Oncology, Fukushima Medical University School of Medicine, Fukushima, Japan. 24Department of Biomedical Statistics and Bioinformatics, Kyoto University Graduate School of Medicine, Kyoto, Japan. 25Department of Breast Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan. 26Breast Oncology Center, The Cancer Institute Hospital of the JFCR, Tokyo, Japan.

田村 研治