ダウンロード数 : ?
ファイル
言語
英語
属性
Original article
著者
森山 茂
倉本 純子
内容記述(抄録等)
The total cell number is the most fundamental data to correctly analyze the development of the tissues and organs. In the present study, we focused on the intestinal epithelium during the period of the intestinal elongation and villi formation. We first measured by using stereology the total number of the intestinal epithelial cells from junction between the stomach and duodenum to the cecum of C57BL/6J mouse embryos at embryonic day (E) 11.5, E13.5, and E15.5 during which the intestine elongates rapidly and the villi start to be formed. We then mathematically analyzed the total epithelial cell number data and formulate the proliferation. The results suggest that the intestinal epithelial cell proliferation is exponential and expressed using the same formula with that for rapidly growing in vitro cultured cells during the log phase. The mechanism which supports the exponential cell growth and the biological significance are discussed.
主題
Intestine
epithelial cells
exponential growth
mouse embryo
掲載誌名
Shimane Journal of Medical Science
38
2
開始ページ
51
終了ページ
57
ISSN
03865959
ISSN(Online)
24332410
発行日
2021-06
NCID
AA00841586
DOI
DOI(SelfDOI)
出版者
Faculty of Medicine, Shimane University
出版者別表記
島根大学医学部
資料タイプ
紀要論文
ファイル形式
PDF
権利関係
Faculty of Medicine, Shimane University
著者版/出版社版
出版社版
部局
医学部
他の一覧