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ファイル
言語
英語
属性
原著論文
著者
石原 朋恵 眼科学講座
海津 幸子 眼科学講座
木村 英人 寿製菓
小山 泰良 寿製菓
松岡 陽太郎 眼科学講座
大平 明弘 眼科学講座
内容記述(抄録等)
Retinal light-induced damage model rats used
in age-related macular degeneration (AMD) studies
clarified that antioxidants decrease the damage.
The seed shells of Japanese horse chestnuts have
antioxidant activity with polyphenols. We studied
that protective effect of the polyphenols from lightinduced
damage. Polyphenols fraction (PF) was extracted
and separated from the seed shells. Antioxidant
activities of PF were measured. Intraperitoneal
administration (IP) and oral administration (PO) of
PF was evaluated protective effects by flash electroretinograms
(ERGs) and outer nuclear layer (ONL)
thickness measurement. IP of PF (100 mg/kg body
weight [BW] and phenyl N-tert-butyl nitrone (PBN)
(50 mg/kg BW) suppressed decrease of ERG amplitude
significantly. And then, decrease of ONL
thickness was suppressed by PF (25, 50 and 100
mg/kg BW) and PBN (50 mg/kg BW). PO of PF
(100 mg/kg BW) protects retinas from light-induced
damage, as well as PBN (10 and 50 mg/kg BW).
Our results indicate that PF alleviates light-induced
retinal damage and potentially useful for the prevention
of AMD.
主題
retina protection
Japanese horse chestnuts
Aesculus turbinata BLUME
polyphenol
antioxidant
掲載誌名
Shimane Journal of Medical Science
34
3
開始ページ
99
終了ページ
107
ISSN
03865959
ISSN(Online)
24332410
発行日
2018-03-31
NCID
AA00841586
出版者
Faculty of Medicine, Shimane University
出版者別表記
島根大学医学部
資料タイプ
紀要論文
ファイル形式
PDF
権利関係
Faculty of Medicine, Shimane University
著者版/出版社版
出版社版
業績ID
e34664
部局
医学部