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ファイル
言語
英語
属性
Original article
著者
HOSSAIN, Kazi Helal
JAHAN, Israt
新林 友美
内容記述(抄録等)
Although infection of Porphyromonas gingivalis (P. gingivalis) is closely correlated with progress of vascular inflammatory diseases, distinctive pathogenesis induced by P. gingivalis is still elusive. We investigated the impact of P. gingivalis lipopolysaccharide (P. gingivalis-LPS) on gene expression in endothelial cells with comparison to Escherichia coli lipopolysaccharide (E. coli-LPS) and zymosan. Here, we showed that the expressions of interleukin-6 and tumor necrosis factor-α mRNA induced by P. gingivalis-LPS are much lower than those by E. coli-LPS, and that the expressions of interleukin-8 and hypoxia inducible factor-2α are also lower than those by zymosan. These effects of P. gingivalis-LPS-mediated alterations of gene expression were cancelled in the absence of fetal bovine serum in culture medium. Of note, P. gingivalis-LPS treatment reduced the gene expressions of tissue factor and plasminogen activating inhibitor-1 as opposed to either E. coli-LPS or zymosan treatment. Our finding suggests that alterations of gene expression pattern in endothelial cells mediated by P. gingivalis-LPS may contribute to the pathogenesis of vascular inflammatory diseases.
主題
Porphyromonas gingivalis
lipopolysaccharide
inflammation
endothelial cells
blood coagulation
掲載誌名
Shimane Journal of Medical Science
37
4
開始ページ
123
終了ページ
132
ISSN
03865959
ISSN(Online)
24332410
発行日
2020-12
NCID
AA00841586
DOI
DOI(SelfDOI)
出版者
Faculty of Medicine, Shimane University
出版者別表記
島根大学医学部
資料タイプ
紀要論文
ファイル形式
PDF
権利関係
Faculty of Medicine, Shimane University
著者版/出版社版
出版社版
部局
医学部
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