ダウンロード数 : ?
ファイル
言語
英語
属性
原著論文
著者
Mu, Qingchun
宇田川 潤
Sun, Tao
内容記述(抄録等)
 Leptin is detected in sera and leptin receptors are expressed in the cerebellum of mouse embryos,suggesting roles of leptin in the cerebellar development. We here injected leptin into the lateral cerebralventricle of leptin receptor-deficient db/db and wild-type mouse embryos and examined the effects on cerebellar development. Leptin was injected on embryonic day(E)14, and the embryos were let to develop by exo utero method till E16 when the cerebellum was examined. Cerebellar volume, number of Math1-immunopositive progenitor cells of granule cells in the external germinal cell layer(EGL)did not differ significantly between db/db and wildtype. However, calbindin-positive Purkinje cells in the Purkinje cell layer(PCL)of db/db tended to be fewer in number and appeared less differentiated than those in wild-type. These results suggest that leptin may not have effect on EGL cells but may promote migration and/or differentiation of progenitors of Purkinje cells in PCL.
掲載誌名
Shimane journal of medical science
27
開始ページ
1
終了ページ
7
ISSN
03865959
ISSN(Online)
24332410
発行日
2010-12-01
NCID
AA00841586
出版者別表記
Shimane University Faculty of Medicine
資料タイプ
紀要論文
ファイル形式
PDF
著者版/出版社版
出版社版
部局
医学部
備考
http://ci.nii.ac.jp/vol_issue/nels/AA00841586_jp.html
このエントリーをはてなブックマークに追加