ダウンロード数 : ?
ファイル
言語
英語
著者
Zhang, Hao
Ma, Lang
Hatta, Toshihisa
内容記述(抄録等)
Adrenocortical X-zone, a transitory cortical region in virgin female and immature male, exists exclusively in mice, and its detailed nature, regression and turnover remain unclear. In this study, the X-zone was investigated in pregnant Jcl:ICR mice, in aspects of morphological traits, cell proliferation by bromodeoxyuridine (BrdU) immunohistochemistry and apoptosis by in situ nick endlabeling of genomic DNA (TUNEL). In the early pregnancy, the intact X-zone, which took more than 30 % of the total adrenocortex, was composed exclusively of non-vacuolated cells, with smaller size and a darker nuclei than other permanent cortical cells. From day 8 of gestation, the X-zone involuted gradually and this degeneration process lasted about one week. There are similarities and discrepancies between Jcl:ICR mice and reported other strains in cellular composition and period of the involution, suggesting strain-difference due to genetic background. BrdU immunohistochemistry demonstrated an apparently more active cell proliferation in the intact X-zone than in other permanent cortical zones. Apoptotic cells were not observed during the X-zone involution by either hematoxylin-eosin staining or TUNEL.
掲載誌名
Shimane journal of medical science
17
1
開始ページ
19
終了ページ
23
ISSN
03865959
ISSN(Online)
24332410
発行日
1999-06-01
NCID
AA00841586
出版者別表記
Shimane Medical University
資料タイプ
紀要論文
ファイル形式
PDF
著者版/出版社版
出版社版
部局
医学部
備考
http://ci.nii.ac.jp/vol_issue/nels/AA00841586_jp.html
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